SRN2 ESCRT-I subunit protein SRN2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SRN2
Official Full Name: ESCRT-I subunit protein SRN2
Primary source: SGD:S000004109
Locus tag: YLR119W
See related: AllianceGenome:SGD:S000004109; FungiDB:YLR119W; VEuPathDB:YLR119W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SRN10; VPL16; VPS37
Summary: Involved in ATP export; protein targeting to membrane; and protein targeting to vacuole. Located in endosome. Part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to several human genes including VPS37A (VPS37A subunit of ESCRT-I); VPS37B (VPS37B subunit of ESCRT-I); and VPS37C (VPS37C subunit of ESCRT-I). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SRN2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (385534..386175)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37.
Title: Structural and functional organization of the ESCRT-I trafficking complex.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to vacuole	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
part_of ESCRT I complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: ESCRT-I subunit protein SRN2

NP_013220.1

Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

385534..386175

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182006.1 → NP_013220.1 TPA: ESCRT-I subunit protein SRN2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013220.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYB7, Q02806, Q99176

UniProtKB/TrEMBL

A7A121, N1P168

Conserved Domains (1) summary

pfam07200
Location:57 → 202

Mod_r; Modifier of rudimentary (Mod(r)) protein