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    PH4alphaNE2 prolyl-4-hydroxylase-alpha NE2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PH4alphaNE2provided by FlyBase
    Official Full Name
    prolyl-4-hydroxylase-alpha NE2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039783
    Locus tag
    Dmel_CG9720
    See related
    AllianceGenome:FB:FBgn0039783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9720; Dmel\CG9720
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in cell migration and sexual reproduction. Predicted to be located in extracellular space. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Used to study prostate cancer. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PH4alphaNE2 in Genome Data Viewer
    Location:
    99F6-99F6; 3-100 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30510083..30512214, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26335805..26337936, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene prolyl-4-hydroxylase-alpha SG1 Neighboring gene uncharacterized protein Neighboring gene mir-4908 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks. Ayroles JF, et al. Genet Res (Camb), 2011 Dec. PMID 22189604, Free PMC Article
    2. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
    3. Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Abrams EW, et al. Development, 2006 Sep. PMID 16914497
    4. A genetic screen in Drosophila for regulators of human prostate cancer progression. Ito S, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25117438
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl-4-hydroxylase-alpha NE2
    Names
    CG9720-PA
    PH4alphaNE2-PA
    NP_733378.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30510083..30512214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170499.2 → NP_733378.1  prolyl-4-hydroxylase-alpha NE2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDS4, Q8STH1, Q9VA61
      Related
      FBpp0085047
      Conserved Domains (5) summary
      smart00702
      Location:342 → 513
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      sd00006
      Location:175 → 200
      TPR; TPR repeat [structural motif]
      pfam07719
      Location:220 → 253
      TPR_2; Tetratricopeptide repeat
      pfam08336
      Location:33 → 161
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
      pfam13432
      Location:176 → 254
      TPR_16; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8STH1 Q8STH1
    Q9VA61 Q9VA61

    Gene LinkOut

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