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    CCL1 TFIIH complex kinase subunit CCL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCL1
    Official Full Name
    TFIIH complex kinase subunit CCL1
    Primary source
    SGD:S000006229
    Locus tag
    YPR025C
    See related
    AllianceGenome:SGD:S000006229; FungiDB:YPR025C; VEuPathDB:YPR025C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of autophagy and transcription by RNA polymerase II. Located in mitochondrion. Part of transcription factor TFIIK complex. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CCL1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (613377..614558, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Eaf3p Neighboring gene i-AAA protease YME1 Neighboring gene alpha,alpha-trehalase ATH1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ccl1, a cyclin associated with protein kinase Kin28, controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription. Valay JG, et al. C R Acad Sci III, 1996 Mar. PMID 8761664
    2. The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae. Valay JG, et al. J Mol Biol, 1993 Nov 20. PMID 8230216
    3. Rig2, a RING finger protein that interacts with the Kin28/Ccl1 CTD kinase in yeast. Faye G, et al. Mol Gen Genet, 1997 Aug. PMID 9294030
    4. The Ccl1-Kin28 kinase complex regulates autophagy under nitrogen starvation. Zhu J, et al. J Cell Sci, 2016 Jan 1. PMID 26567215
    5. Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. van Eeuwen T, et al. Sci Adv, 2021 Apr. PMID 33827808, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIK complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TFIIH complex kinase subunit CCL1
    NP_015350.1
    • Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p; regulates the activity of Kin28p, a TFIIH-associated carboxy-terminal domain (CTD) kinase that facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex, and has a minor role in RNAPII transcription; subunit of TFIIK, a TFIIH subassembly; human homolog CCNH allows growth of a yeast ccl1 temperature-sensitive mutant at restrictive temperature

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      613377..614558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184122.1 → NP_015350.1  TPA: TFIIH complex kinase subunit CCL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W435, P37366
      UniProtKB/TrEMBL
      A6ZWR8, B3LL86, B5VTI3, C7GQB3, C8ZJ49
      Conserved Domains (1) summary
      TIGR00569
      Location:49 → 376
      ccl1; cyclin ccl1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37366.1

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