NAT5 peptide alpha-N-acetyltransferase subunit NAT5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NAT5
Official Full Name: peptide alpha-N-acetyltransferase subunit NAT5
Primary source: SGD:S000005779
Locus tag: YOR253W
See related: AllianceGenome:SGD:S000005779; FungiDB:YOR253W; VEuPathDB:YOR253W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ARD2; NAA50; ROG2
Summary: Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Part of NatA complex. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NAT5 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (804377..804907)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study quantitatively compared the Nt-acetylomes of wild-type yeast S. cerevisiae expressing the endogenous yeast Naa50 (yNaa50), the congenic strain lacking yNaa50, and an otherwise identical strain expressing human Naa50 (hNaa50).
Title: N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide-methionine-alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NatA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatA complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptide alpha-N-acetyltransferase subunit NAT5

NP_014896.3

EC 2.3.1.258

Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

804377..804907

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183672.3 → NP_014896.3 TPA: peptide alpha-N-acetyltransferase subunit NAT5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014896.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2V4, Q08689

UniProtKB/TrEMBL

A6ZP91, B3LJS1, B5VSD4, C7GWD6, C8ZH05, G2WNC1, N1NXA3

Conserved Domains (1) summary

pfam00583
Location:63 → 147

Acetyltransf_1; Acetyltransferase (GNAT) family