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    CLN1 cyclin CLN1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CLN1
    Official Full Name
    cyclin CLN1
    Primary source
    SGD:S000004812
    Locus tag
    YMR199W
    See related
    AllianceGenome:SGD:S000004812; FungiDB:YMR199W; VEuPathDB:YMR199W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of protein phosphorylation and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); endocrine gland cancer (multiple); hematologic cancer (multiple); and hepatitis B. Orthologous to several human genes including CCNA1 (cyclin A1); CCNA2 (cyclin A2); and CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CLN1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (662644..664284)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene v-SNARE protein VTI1 Neighboring gene Cik1p Neighboring gene Rot1p Neighboring gene DNA repair protein RAD14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast. Baroni MD, et al. Nature, 1994 Sep 22. PMID 8090203
    2. Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Amon A, et al. Cell, 1994 Jul 1. PMID 8020094
    3. Control of yeast filamentous-form growth by modules in an integrated molecular network. Prinz S, et al. Genome Res, 2004 Mar. PMID 14993204, Free PMC Article
    4. An enhancer trap line associated with a D-class cyclin gene in Arabidopsis. Swaminathan K, et al. Plant Physiol, 2000 Dec. PMID 11115883, Free PMC Article
    5. CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast. Mai B, et al. Mol Cell Biol, 2000 Jan. PMID 10611226, Free PMC Article

    See all (200) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The global role of cyclin-specific phosphorylation has been resolved whereby a cyclin docking motif, LxF, that mediates binding of replication factor Cdc6 to mitotic cyclin has been uncovered.
      Title: Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle.
    2. The region between amino acids 225 and 299 of Cln2 is sufficient to confer Cln2-specific functionality to Cln1.
      Title: Molecular basis of the functional distinction between Cln1 and Cln2 cyclins.
    3. Ime2 does not directly catalyze Sic1 phosphorylation to target it for destabilization as Cln1,-2/Cdk1 do during the cell cycle
      Title: Yeast IME2 functions early in meiosis upstream of cell cycle-regulated SBF and MBF targets.
    4. positive-feedback-amplified expression of Cln1 and Cln2 simultaneously drives robust budding and rapid, coherent regulon expression
      Title: Positive feedback of G1 cyclins ensures coherent cell cycle entry.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin CLN1
    NP_013926.1
    • G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      662644..664284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182706.1 → NP_013926.1  TPA: cyclin CLN1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013926.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W024, P20437
      UniProtKB/TrEMBL
      A6ZMR1, B3LM87, B5VPW8, C7GRF2, N1NYY9
      Conserved Domains (1) summary
      COG5024
      Location:31 → 539
      COG5024; Cyclin [Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20437.2

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