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    Abhd17a abhydrolase domain containing 17A [ Mus musculus (house mouse) ]

    Gene ID: 216169, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abhd17aprovided by MGI
    Official Full Name
    abhydrolase domain containing 17Aprovided by MGI
    Primary source
    MGI:MGI:106388
    See related
    Ensembl:ENSMUSG00000003346 AllianceGenome:MGI:106388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam108a; D10Bwg1364e; 1700013O15Rik
    Summary
    Predicted to enable palmitoyl-(protein) hydrolase activity. Predicted to be involved in several processes, including negative regulation of NLRP3 inflammasome complex assembly; protein depalmitoylation; and regulation of protein localization. Predicted to be located in nuclear speck; postsynaptic density; and recycling endosome membrane. Predicted to be active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic recycling endosome membrane. Orthologous to human ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 251.7), adrenal adult (RPKM 194.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abhd17a in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80419483..80426199, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80583649..80590341, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:80032416-80032717 Neighboring gene Kruppel-like transcription factor 16 Neighboring gene STARR-positive B cell enhancer ABC_E11446 Neighboring gene predicted gene, 26710 Neighboring gene STARR-positive B cell enhancer ABC_E2950 Neighboring gene STARR-positive B cell enhancer ABC_E6883 Neighboring gene secretory carrier membrane protein 4 Neighboring gene adenosine deaminase, tRNA-specific 3 Neighboring gene microRNA 6912

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons. Yan P, et al. Cell Death Dis, 2022 Sep 12. PMID 36097267, Free PMC Article
    2. A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. van der Weyden L, et al. G3 (Bethesda), 2020 Jun 1. PMID 32245826, Free PMC Article
    3. Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Puttagunta R, et al. Genome Res, 2000 Sep. PMID 10984455, Free PMC Article
    4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11699, MGC90979

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of NLRP3 inflammasome complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha/beta hydrolase domain-containing protein 17A
    Names
    abhydrolase domain-containing protein 17A
    abhydrolase domain-containing protein FAM108A
    family with sequence similarity 108, member A
    mFLJ00358 protein
    protein ABHD17A
    NP_663396.1
    XP_006513567.1
    XP_017169383.1
    XP_030100883.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145421.2 → NP_663396.1  alpha/beta hydrolase domain-containing protein 17A

      See identical proteins and their annotated locations for NP_663396.1

      Status: VALIDATED

      Source sequence(s)
      AC152058
      Consensus CDS
      CCDS24027.1
      UniProtKB/Swiss-Prot
      Q5DU54, Q99JW1
      Related
      ENSMUSP00000003436.6, ENSMUST00000003436.12
      Conserved Domains (1) summary
      COG1073
      Location:113 → 305
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80419483..80426199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513504.3 → XP_006513567.1  alpha/beta hydrolase domain-containing protein 17A isoform X2

      Conserved Domains (1) summary
      COG1073
      Location:117 → 240
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    2. XM_017313894.3 → XP_017169383.1  alpha/beta hydrolase domain-containing protein 17A isoform X1

      UniProtKB/Swiss-Prot
      Q5DU54, Q99JW1
      Conserved Domains (1) summary
      COG1073
      Location:113 → 305
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    3. XM_030245023.2 → XP_030100883.1  alpha/beta hydrolase domain-containing protein 17A isoform X2

      Conserved Domains (1) summary
      COG1073
      Location:117 → 240
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JW1.1 GenPept UniProtKB/Swiss-Prot:Q99JW1

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