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    scramb1 scramblase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scramb1provided by FlyBase
    Official Full Name
    scramblase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0052056
    Locus tag
    Dmel_CG32056
    See related
    AllianceGenome:FB:FBgn0052056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32056; CG6590; CT20492; Dmel\CG32056; Scramb1
    Summary
    Predicted to enable phospholipid scramblase activity. Involved in chemical synaptic transmission. Predicted to be active in plasma membrane. Is expressed in adult head; adult heart; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to several human genes including PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See scramb1 in Genome Data Viewer
    Location:
    67D11-67D11; 3-32 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10220483..10225240, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10213583..10218340, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44542 Neighboring gene long non-coding RNA:CR45403

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Scramblases modulate synaptic transmission. Acharya U, et al. J Cell Biol, 2006 Apr 10. PMID 16606691, Free PMC Article
    2. The coagulation of insect hemolymph. Theopold U, et al. Cell Mol Life Sci, 2002 Feb. PMID 11915949, Free PMC Article
    3. Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm. Castillo-Mancho V, et al. Cell Mol Life Sci, 2024 Jun 15. PMID 38878170, Free PMC Article
    4. A humoral stress response protects Drosophila tissues from antimicrobial peptides. Rommelaere S, et al. Curr Biol, 2024 Apr 8. PMID 38484734
    5. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    scramblase 1
    Names
    CG32056-PA
    CG32056-PB
    CG32056-PC
    scramb1-PA
    scramb1-PB
    scramb1-PC
    scramblase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10220483..10225240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168404.2 → NP_729601.1  scramblase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQD7
      Related
      FBpp0076031
      Conserved Domains (1) summary
      pfam03803
      Location:1 → 221
      Scramblase

    2. NM_140132.3 → NP_648389.3  scramblase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648389.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TV8, Q9VT88
      Conserved Domains (2) summary
      pfam03803
      Location:184 → 404
      Scramblase; Scramblase
      pfam12067
      Location:61 → 129
      Sox_C_TAD; Sox C-terminal transactivation domain

    3. NM_168403.2 → NP_729600.1  scramblase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQD8
      Related
      FBpp0076032
      Conserved Domains (1) summary
      pfam03803
      Location:101 → 320
      Scramblase; Scramblase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQD7 Q8IQD7
    Q8IQD8 Q8IQD8
    Q9VT88 Q9VT88

    Gene LinkOut

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