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    alpha-Est5 alpha-Esterase-5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Est5provided by FlyBase
    Official Full Name
    alpha-Esterase-5provided by FlyBase
    Primary source
    FLYBASE:FBgn0261393
    Locus tag
    Dmel_CG1089
    See related
    AllianceGenome:FB:FBgn0261393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aE5; alphaE5; CG1089; D; DmalphaE5; Dmel\CG1089; Est-9; Est-c; Est-C; EST-C; EST9; EstC; ESTC
    Summary
    Enables carboxylesterase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Est5 in Genome Data Viewer
    Location:
    84D9-84D9; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7533496..7536390, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3359218..3362112, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rtnl2 Neighboring gene alpha-Tubulin at 84D Neighboring gene alpha-Esterase-4 Neighboring gene antisense RNA:CR46128 Neighboring gene alpha-Esterase-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular population genetics of the alpha-esterase5 gene locus in original and colonized populations of Drosophila buzzatii and its sibling Drosophila koepferae. Piccinali RV, et al. J Mol Evol, 2007 Feb. PMID 17160646
    2. A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymes. Kojima K, et al. Biochem Genet, 1970 Oct. PMID 5489766
    3. Studies of a homologous gene-enzyme system, esterase C, in Drosophila melanogaster and Drosophila simulans. Triantaphyllidis CD, et al. Biochem Genet, 1973 Apr. PMID 4197378
    4. Isozyme variability in species of the genus Drosophila. VII. Genotype-environment relationships in populations of D. melanogaster from the Eastern United States. Johnson FM, et al. Biochem Genet, 1973 Oct. PMID 4201524
    5. Multiple paternity in two natural populations (orchard and vineyard) of Drosophila. Ochando MD, et al. Proc Natl Acad Sci U S A, 1996 Oct 15. PMID 8876212, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleotide variation in a fragment of alpha-esterase5 (alphaE5)in a fragment of the gene econding in original (Argentinian) and colonized (Australian) populations of Drosophila.
      Title: Molecular population genetics of the alpha-esterase5 gene locus in original and colonized populations of Drosophila buzzatii and its sibling Drosophila koepferae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c7534115-7534017 mobile_element_type = transposon:INE-1{}1794

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    enables serine hydrolase activity HDA PubMed 

    General protein information

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    Preferred Names
    alpha-Esterase-5
    Names
    CG1089-PA
    CG1089-PB
    alpha-Est5-PA
    alpha-Est5-PB
    esterase C
    esterase-C
    fragment D
    NP_001246965.1
    NP_524265.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7533496..7536390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260036.2 → NP_001246965.1  alpha-Esterase-5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6V8, Q24198
      Conserved Domains (1) summary
      pfam00135
      Location:7 → 510
      COesterase; Carboxylesterase family

    2. NM_079541.4 → NP_524265.3  alpha-Esterase-5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524265.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24198, Q95U30, Q9VIB9
      Related
      FBpp0081071
      Conserved Domains (1) summary
      pfam00135
      Location:5 → 509
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6V8 A0A0B4K6V8
    Q24198 Q24198
    Q95U30 Q95U30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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