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    Idgf1 Imaginal disc growth factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34978, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Idgf1provided by FlyBase
    Official Full Name
    Imaginal disc growth factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0020416
    Locus tag
    Dmel_CG4472
    See related
    AllianceGenome:FB:FBgn0020416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS02780.5; CG4472; Dmel\CG4472; DmIDGF1; IDGF; IDGF-1; idgf1; IDGF1; ldgf1
    Summary
    Enables imaginal disc growth factor receptor binding activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and epithelium regeneration. Predicted to be active in extracellular region. Is expressed in several structures, including adult head; amnioproctodeal invagination; embryonic/larval fat body; epithelial furrow; and female germline cell. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Idgf1 in Genome Data Viewer
    Location:
    36A1-36A1; 2-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16445278..16446793)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16445278..16446793)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene calcium-binding protein 1 Neighboring gene juvenile hormone acid methyltransferase Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 2 Neighboring gene Imaginal disc growth factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CO2 exposure drives a rapid pH response in live adult Drosophila. Zimmerman SG, et al. PLoS One, 2024. PMID 38625910, Free PMC Article
    2. Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism. Towler BP, et al. PLoS Genet, 2020 Dec. PMID 33370287, Free PMC Article
    3. Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster. Varela PF, et al. J Biol Chem, 2002 Apr 12. PMID 11821393
    4. Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster. Zimmerman SG, et al. Genetics, 2017 Jun. PMID 28404605, Free PMC Article
    5. Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions. Zurovcova M, et al. Insects, 2019 Oct 20. PMID 31635152, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables imaginal disc growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelium regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    imaginal disc growth factor 1
    Names
    CG4472-PA
    Idgf1-PA
    imaginal disc growth factor1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16445278..16446793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057910.5 → NP_477258.1  imaginal disc growth factor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477258.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96664, Q8MM24, Q8MM30, Q8MM31, Q8MM38, Q8MM92, Q8MX42, Q8MX43, Q8MX44, Q8MX45, Q8MX46, Q8MX47, Q8MX48, Q8MX49, Q8MX50, Q9V3P8
      Related
      FBpp0080417
      Conserved Domains (2) summary
      cd02873
      Location:23 → 438
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:24 → 417
      Glyco_18; Glyco_18 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MM24.2 Q8MM24

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