U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    smash smallish [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40583, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    smashprovided by FlyBase
    Official Full Name
    smallishprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263346
    Locus tag
    Dmel_CG43427
    See related
    AllianceGenome:FB:FBgn0263346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.95; CG1054; CG1055; CG14653; CG18253; CG31531; CG31534; CG43427; Dmel\CG43427; Smash
    Old locus tag
    Dmel_CG31531; Dmel_CG31534
    Summary
    Predicted to enable microtubule binding activity. Involved in morphogenesis of embryonic epithelium and protein localization to cell-cell junction. Located in zonula adherens. Is expressed in several structures, including adult fat body; epithelium; gut section; larval muscle cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See smash in Genome Data Viewer
    Location:
    82D1-82D2; 3-47.1 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4659579..4712193)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (485301..537915)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Karyopherin beta 3 Neighboring gene long non-coding RNA:CR44156 Neighboring gene spartin Neighboring gene long non-coding RNA:CR44157 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44923 Neighboring gene eukaryotic translation initiation factor 3 subunit f1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role of the smallish gene during Drosophila eye development. Tanaka R, et al. Gene, 2019 Feb 5. PMID 30359736
    2. The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. Beati H, et al. J Cell Biol, 2018 Mar 5. PMID 29358210, Free PMC Article
    3. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Lee C, et al. Mol Cell Biol, 2008 May. PMID 18332113, Free PMC Article
    4. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Tsubouchi A, et al. Curr Biol, 2012 Nov 20. PMID 23103192, Free PMC Article
    5. Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of Drosophila melanogaster. Takahashi KH, et al. Evolution, 2012 Sep. PMID 22946809

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 4690692-4691118 mobile_element_type = transposon:INE-1{}4475

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in zonula adherens IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    smallish
    Names
    CG43427-PE
    CG43427-PF
    CG43427-PG
    CG43427-PH
    CG43427-PI
    CG43427-PJ
    CG43427-PM
    CG43427-PN
    CG43427-PO
    CG43427-PP
    smash
    smash-PE
    smash-PF
    smash-PG
    smash-PH
    smash-PI
    smash-PJ
    smash-PM
    smash-PN
    smash-PO
    smash-PP

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4659579..4712193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259984.2 → NP_001246913.1  smallish, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6R6
      Conserved Domains (1) summary
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    2. NM_001259983.2 → NP_001246912.1  smallish, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K615
      Conserved Domains (2) summary
      pfam00412
      Location:1494 → 1530
      LIM; LIM domain
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    3. NM_001259982.2 → NP_001246911.1  smallish, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246911.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K5Z4
      Conserved Domains (1) summary
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    4. NM_001144532.3 → NP_001138004.2  smallish, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138004.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0T2
      Conserved Domains (1) summary
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    5. NM_001144533.3 → NP_001138005.2  smallish, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138005.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0T1
      Conserved Domains (2) summary
      smart00132
      Location:1463 → 1521
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    6. NM_169015.3 → NP_730865.1  smallish, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIU0, Q0KIC3, Q8SX99
      UniProtKB/TrEMBL
      E2QCZ8
      Related
      FBpp0301005
      Conserved Domains (1) summary
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    7. NM_176399.3 → NP_788576.1  smallish, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIU0, Q0KIC3, Q8SX99
      UniProtKB/TrEMBL
      E2QCZ8
      Related
      FBpp0301006
      Conserved Domains (1) summary
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    8. NM_169014.3 → NP_730864.1  smallish, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730864.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIU0, Q0KIC3, Q8SX99
      UniProtKB/TrEMBL
      E2QCZ8
      Related
      FBpp0301004
      Conserved Domains (1) summary
      pfam15949
      Location:14 → 152
      DUF4757; Domain of unknown function (DUF4757)

    9. NM_176400.1 → NP_788577.1  smallish, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788577.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BB6, Q8T0J7
      Conserved Domains (1) summary
      PRK13335
      Location:66 → 160
      PRK13335; superantigen-like protein; Reviewed

    10. NM_141231.4 → NP_649488.2  smallish, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649488.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0J7, Q9VN49
      Conserved Domains (1) summary
      smart00132
      Location:819 → 877
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K5Z4 A0A0B4K5Z4
    A0A0B4K615 A0A0B4K615
    A0A0B4K6R6 A0A0B4K6R6
    B7Z0T1 B7Z0T1
    B7Z0T2 B7Z0T2
    E2QCZ8 E2QCZ8
    Q0KIC3.1 Q0KIC3
    Q86BB6 Q86BB6
    Q8T0J7 Q8T0J7
    Q9VN49 Q9VN49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools