CG8888 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG8888provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0033679
Locus tag: Dmel_CG8888
See related: AllianceGenome:FB:FBgn0033679
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG8888
Summary: Predicted to enable 3-hydroxybutyrate dehydrogenase activity. Predicted to be involved in steroid metabolic process. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; corpus allatum primordium; embryonic/larval corpus allatum; and larval muscle system. Used to study chromosome 3q29 microdeletion syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13. Orthologous to several human genes including BDH1 (3-hydroxybutyrate dehydrogenase 1); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and SDR9C7 (short chain dehydrogenase/reductase family 9C member 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 48D8-48E1; 2-66 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12064565..12079543, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7952070..7967048, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0793 (e-PCR)
- UniSTS:73870

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3-hydroxybutyrate dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: uncharacterized protein

Names: CG8888-PA

NP_610724.1

EC 1.-.-.-

EC 1.1.1.239

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12064565..12079543 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136880.3 → NP_610724.1 uncharacterized protein Dmel_CG8888 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610724.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K3N4

Related

FBpp0087129

Conserved Domains (2) summary

pfam00106
Location:96 → 293

adh_short; short chain dehydrogenase

cl21454
Location:96 → 380

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins