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    Iris iris [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Irisprovided by FlyBase
    Official Full Name
    irisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031305
    Locus tag
    Dmel_CG4715
    See related
    AllianceGenome:FB:FBgn0031305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4715; CG4715-env; Dm-cF; Dmel\CG4715
    Summary
    Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Iris in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1132332..1134098, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1132332..1134098, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pinocchio Neighboring gene TBC1 domain family member 23 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cellular Drosophila melanogaster protein with similarity to baculovirus F envelope fusion proteins. Lung O, et al. J Virol, 2005 Jul. PMID 15956544, Free PMC Article
    2. [Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome]. Makhnovskii PA, et al. Mol Biol (Mosk), 2016 May-Jun. PMID 27414781
    3. Positive selection of Iris, a retroviral envelope-derived host gene in Drosophila melanogaster. Malik HS, et al. PLoS Genet, 2005 Oct. PMID 16244705, Free PMC Article
    4. Allelic imbalance in Drosophila hybrid heads: exons, isoforms, and evolution. Graze RM, et al. Mol Biol Evol, 2012 Jun. PMID 22319150, Free PMC Article
    5. Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis. Zhu L, et al. RNA Biol, 2019 Oct. PMID 31195914, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iris is not involved in immune responses, but it apparently performs a cell function that is inhibited in stress.
      Title: [Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome].
    2. Iris has "switched sides," having been recruited by host genomes to combat baculoviruses and retroviruses, which employ homologous envelope genes to mediate infection
      Title: Positive selection of Iris, a retroviral envelope-derived host gene in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    iris
    Names
    CG4715-PA
    Iris-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1132332..1134098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134726.3 → NP_608570.1  iris [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q30CQ7, Q30CR0, Q9VPX0
      Related
      FBpp0077651
      Conserved Domains (2) summary
      pfam12259
      Location:176 → 530
      DUF3609; Protein of unknown function (DUF3609)
      pfam12272
      Location:1 → 155
      DUF3610; Protein of unknown function (DUF3610)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPX0 Q9VPX0

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