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    igl igloo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    iglprovided by FlyBase
    Official Full Name
    iglooprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013467
    Locus tag
    Dmel_CG18285
    See related
    AllianceGenome:FB:FBgn0013467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18285; Dmel\CG18285; Igl
    Summary
    Enables calmodulin binding activity. Located in cell cortex. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic head sensory system; and sensory nervous system primordium. Orthologous to human GAP43 (growth associated protein 43) and SPA17 (sperm autoantigenic protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See igl in Genome Data Viewer
    Location:
    51E3-51E5; 2-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15155437..15190292)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11042942..11077797)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43831 Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 51E Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Igloo, a GAP-43-related gene expressed in the developing nervous system of Drosophila. Neel VA, et al. Development, 1994 Aug. PMID 7925024
    2. Calmodulin signaling via the IQ motif. Bähler M, et al. FEBS Lett, 2002 Feb 20. PMID 11911888
    3. Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling. Benetka W, et al. Cell Cycle, 2008 Dec. PMID 19029837
    4. Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types. Yeung K, et al. Commun Biol, 2022 Dec 14. PMID 36517671, Free PMC Article
    5. The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle. Saunders RD, et al. J Cell Biol, 1997 May 19. PMID 9151690, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    igloo
    Names
    CG18285-PA
    CG18285-PB
    CG18285-PC
    igl-PA
    igl-PB
    igl-PC
    invertebrate GAP-43-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15155437..15190292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274059.1 → NP_001260988.1  igloo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T29
      Conserved Domains (2) summary
      smart00015
      Location:98 → 117
      IQ; Calmodulin-binding motif
      cd22307
      Location:51 → 91
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

    2. NM_057712.5 → NP_477060.1  igloo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JPS2
      Related
      FBpp0086494
      Conserved Domains (2) summary
      smart00015
      Location:216 → 235
      IQ; Calmodulin-binding motif
      cd22307
      Location:74 → 129
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

    3. NM_057713.5 → NP_477061.1  igloo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T29
      Related
      FBpp0086495
      Conserved Domains (2) summary
      smart00015
      Location:98 → 117
      IQ; Calmodulin-binding motif
      cd22307
      Location:51 → 91
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JPS2 Q7JPS2
    Q95T29 Q95T29

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