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    Vps26 Vacuolar protein sorting 26 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps26provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 26provided by FlyBase
    Primary source
    FLYBASE:FBgn0014411
    Locus tag
    Dmel_CG14804
    See related
    AllianceGenome:FB:FBgn0014411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    131F2S; anon-sts13; CG14804; Dmel\CG14804; DmVps26; dvps26; dVps26; Dvps26; EG:63B12.8; ESTS:131F2S; vps26; VPS26
    Summary
    Enables cargo receptor activity. Involved in endosome to plasma membrane protein transport and regulation of Wnt signaling pathway. Part of retromer complex. Is expressed in adult head; adult heart; and photoreceptor neurons. Used to study brain cancer. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to several human genes including VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps26 in Genome Data Viewer
    Location:
    2B13-2B13; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1873853..1876474)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1767886..1770507)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 18 Neighboring gene Peroxin 5 Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase assembly factor 8 Neighboring gene trithorax-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Retromer regulates apical-basal polarity through recycling Crumbs. Zhou B, et al. Dev Biol, 2011 Dec 1. PMID 21958744
    2. Phospholipase D and retromer promote recycling of TRPL ion channel via the endoplasmic reticulum. Wagner K, et al. Traffic, 2022 Jan. PMID 34719094
    3. Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2). Linhart R, et al. Mol Neurodegener, 2014 Jun 11. PMID 24915984, Free PMC Article
    4. Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain. Lin G, et al. Cell Metab, 2018 Oct 2. PMID 29909971
    5. The retromer subunit Vps26 mediates Notch signaling during Drosophila oogenesis. Starble R, et al. Mech Dev, 2018 Feb. PMID 29031909

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cargo receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosome to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of retromer, cargo-selective complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting 26
    Names
    CG14804-PA
    Vps26-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1873853..1876474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130596.3 → NP_569952.2  vacuolar protein sorting 26 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569952.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46088, Q4QQB4, Q95SD6, Q9W552
      Related
      FBpp0070298
      Conserved Domains (1) summary
      pfam03643
      Location:6 → 280
      Vps26; Vacuolar protein sorting-associated protein 26
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W552.1 Q9W552

    Gene LinkOut

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