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    Nmt N-myristoyl transferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmtprovided by FlyBase
    Official Full Name
    N-myristoyl transferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020392
    Locus tag
    Dmel_CG7436
    See related
    AllianceGenome:FB:FBgn0020392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153290_at; CG7436; Dmel\CG7436; dNMT; l(3)j1c7; l(3)j1C7; nmt; Nmt1
    Summary
    Enables glycylpeptide N-tetradecanoyltransferase activity. Predicted to be involved in protein localization to membrane. Located in membrane. Is expressed in several structures, including adult head; central brain primordium; larval visceral muscle cell; mesoderm; and visceral muscle primordium. Orthologous to human NMT1 (N-myristoyltransferase 1) and NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nmt in Genome Data Viewer
    Location:
    66B10-66B11; 3-22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8176135..8178429, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8169235..8171529, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RecQ4 helicase Neighboring gene methuselah-like 7 Neighboring gene UDP-xylose synthase Neighboring gene estrogen-related receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and expression of Drosophila myristoyl-CoA: protein N-myristoyl transferase: evidence for proteolytic processing and membrane localisation. Ntwasa M, et al. J Cell Sci, 1997 Jan. PMID 9044045
    2. Drosophila embryos lacking N-myristoyltransferase have multiple developmental defects. Ntwasa M, et al. Exp Cell Res, 2001 Jan 15. PMID 11139338
    3. The biology and enzymology of protein N-myristoylation. Farazi TA, et al. J Biol Chem, 2001 Oct 26. PMID 11527981
    4. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Allada R, et al. Cell, 1998 May 29. PMID 9630223
    5. Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiation. Herrig DK, et al. Evolution, 2014 Mar. PMID 24152112, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycylpeptide N-tetradecanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein myristoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dorsal closure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-myristoyl transferase
    Names
    CG7436-PA
    Nmt-PA
    NP_523969.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8176135..8178429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079245.3 → NP_523969.1  N-myristoyl transferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61613, Q9XZ55
      Related
      FBpp0076451
      Conserved Domains (2) summary
      pfam01233
      Location:112 → 268
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:284 → 459
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61613.2 O61613

    Gene LinkOut

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