Pex19 Peroxin 19 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pex19provided by FlyBase
Official Full Name: Peroxin 19provided by FlyBase
Primary source: FLYBASE:FBgn0032407
Locus tag: Dmel_CG5325
See related: AllianceGenome:FB:FBgn0032407
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:GH03076; CG5325; DmelPex19; Dmel\CG5325; Pex-19; PEX19
Summary: Predicted to enable peroxisome membrane targeting sequence binding activity. Involved in peroxisome organization. Located in cytosol and peroxisome. Is expressed in several structures, including adult head; embryonic cortex; germ band; posterior midgut primordium; and yolk. Used to study Zellweger syndrome and peroxisome biogenesis disorder 12A. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 12A. Orthologous to human PEX19 (peroxisomal biogenesis factor 19). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12091822..12095250)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12091822..12095250)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

a Drosophila Pex19 mutant is lethal due to a deficit in medium-chain fatty acids
Title: Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables peroxisome membrane targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein import into peroxisome membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed