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    BoYb Brother of Yb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BoYbprovided by FlyBase
    Official Full Name
    Brother of Ybprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037205
    Locus tag
    Dmel_CG11133
    See related
    AllianceGenome:FB:FBgn0037205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    boYb; CG11133; Dmel\CG11133
    Summary
    Predicted to enable ATP binding activity and nucleic acid binding activity. Involved in primary piRNA processing and secondary piRNA processing. Located in Yb body. Is expressed in organism and spermatozoon. Orthologous to human TDRD12 (tudor domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BoYb in Genome Data Viewer
    Location:
    80B2-80B2; 3-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22901912..22905470)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22895012..22898570)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44689 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45661 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading. Dou K, et al. J Genet Genomics, 2020 Apr 20. PMID 32499180, Free PMC Article
    2. Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Seroude L, et al. Aging Cell, 2002 Oct. PMID 12882353
    3. Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription. Tsai SY, et al. PLoS Genet, 2021 Feb. PMID 33524038, Free PMC Article
    4. Retrovirus reactivation in CHMP2BIntron5 models of frontotemporal dementia. Fort-Aznar L, et al. Hum Mol Genet, 2020 Sep 29. PMID 32628265, Free PMC Article
    5. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. Szakmary A, et al. J Cell Biol, 2009 May 18. PMID 19433453, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila TUDOR domain-containing proteins interact with Vreteno and the Tdrd12 family, essential primary piRNA pathway factors
      Title: A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ-line stem cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secondary piRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Yb body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brother of Yb
    Names
    BoYb-PA
    CG11133-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22901912..22905470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141173.2 → NP_649430.1  brother of Yb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YTZ8, Q9VNP5
      Related
      FBpp0078210
      Conserved Domains (1) summary
      cl21455
      Location:81 → 263
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNP5.1 Q9VNP5

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