eIF2gamma eukaryotic translation initiation factor 2 subunit gamma [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF2gammaprovided by FlyBase
Official Full Name: eukaryotic translation initiation factor 2 subunit gammaprovided by FlyBase
Primary source: FLYBASE:FBgn0263740
Locus tag: Dmel_CG43665
See related: AllianceGenome:FB:FBgn0263740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 51kDa protein; CG43665; CG6476; Dmel\CG43665; eIF-2G; eIF-2gamma; eIF2-gamma; eIF2G
Summary: Predicted to enable methionyl-initiator methionine tRNA binding activity and translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to be part of eukaryotic 43S preinitiation complex; eukaryotic translation initiation factor 2 complex; and multi-eIF complex. Is expressed in several structures, including Malpighian tubule primordium; adult heart; embryonic/larval midgut primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma) and EIF2S3B (eukaryotic translation initiation factor 2 subunit gamma B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88E6-88E8; 3-56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15257844..15263458, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11083566..11089180, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.
Title: A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.
RNA helicase interacts with the well-characterized histone methyltransferase SU(VAR)3-9 via its N-terminus, which provides a potential mechanism for the targeting of H3K9 methylation to highly regulated genes.
Title: The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster.
the SUUR protein is required for the SU(VAR)3-9 enzyme to bind to the salivary gland polytene chromosomes
Title: The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster.
Data show that animals with reduced heterochromatin, such as Stat92E transheterozygotes, Su(var)205 heterozygotes, or Su(var)3-9 transheterozygotes, were less viable than wild-type controls.
Title: Unphosphorylated STAT and heterochromatin protect genome stability.
The genetic interactions between dSETDB1 and Su(var)3-9 mutations emphasize the importance of maintaining the activities of these histone methyltransferases in balance for normal genome function.
Title: Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.
results indicate that dSETDB1 and SU(VAR)3-9 act together with distinct roles during oogenesis, with dsetdb1 being of particular importance due to its germline stem cell-specific function and more severe mutant phenotype
Title: dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster.
describe how, in double mutants for Su(var)3-9 and Suppressor of Under-Replication genes encoding two structural proteins of heterochromatin, new banded heterochromatic segments appear in all polytene chromosomes
Title: High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants.
Saturation transfer difference NMR measurements were performed to investigate the interaction of S-adenosyl-l-methionine (AdoMet) with SU(VAR)3-9
Title: Saturation transfer difference measurements with SU(VAR)3-9 and S-adenosyl-L-methionine.
Su(var)3-7 expression is sufficient to induce Su(var)3-9-dependent ectopic heterochromatinisation; there may be a functional link between Su(var)3-7 and the histone-methyltransferase Su(var)3-9
Title: Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation.
Pericentric heterochromatin is heterogeneous in its requirement for SU(VAR)3-9 with respect to the establishment of the condensed state, time of replication, and DNA polytenization.
Title: The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables methionyl-initiator methionine tRNA binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of translation preinitiation complex	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of multi-eIF complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 2 subunit gamma

Names: CG43665-PB; CG43665-PC; CG43665-PD; eIF2gamma-PB; eIF2gamma-PC; eIF2gamma-PD; eukaryotic initiation factor 2gamma; gamma subunit of the translation initiation factor eIF2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15257844..15263458 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275658.1 → NP_001262587.1 eukaryotic translation initiation factor 2 subunit gamma, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262587.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24208, Q9VFA7

UniProtKB/TrEMBL

A0A0B4KGP8

Conserved Domains (1) summary

PTZ00327
Location:11 → 465

PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
NM_169629.2 → NP_731993.1 eukaryotic translation initiation factor 2 subunit gamma, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731993.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24208, Q9VFA7

UniProtKB/TrEMBL

A0A0B4KGP8

Related

FBpp0302537

Conserved Domains (1) summary

PTZ00327
Location:11 → 465

PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
NM_169630.2 → NP_731994.1 eukaryotic translation initiation factor 2 subunit gamma, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731994.1

Status: REVIEWED

UniProtKB/TrEMBL

Q53XD3

Related

FBpp0302538

Conserved Domains (4) summary

cd01888
Location:33 → 239

eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)

PTZ00327
Location:15 → 457

PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

cd03688
Location:240 → 353

eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2

cd15490
Location:356 → 450

eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma