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    MRG15 MORF-related gene 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRG15provided by FlyBase
    Official Full Name
    MORF-related gene 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0027378
    Locus tag
    Dmel_CG6363
    See related
    AllianceGenome:FB:FBgn0027378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6363; Dmel\CG6363; DmMRG15; dMrg15; dMRG15; Dmrg15; l(3)j6A3; MRG-15; mrg15; Mrg15
    Summary
    Enables chromatin binding activity; enzyme regulator activity; and methylated histone binding activity. Involved in several processes, including chromatin remodeling; chromosome separation; and positive regulation of gene expression. Located in nucleus. Part of NuA4 histone acetyltransferase complex and histone methyltransferase complex. Is expressed in several structures, including adult head; central brain primordium; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to several human genes including MORF4L1 (mortality factor 4 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MRG15 in Genome Data Viewer
    Location:
    88E11-88E11; 3-56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15276440..15278109, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11102162..11103831, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene Centrosomal protein 190kD Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene lethal (3) neo43 Neighboring gene Tropomyosin 1 Neighboring gene uncharacterized protein Neighboring gene Tropomyosin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FlyORF-TaDa allows rapid generation of new lines for in vivo cell-type-specific profiling of protein-DNA interactions in Drosophila melanogaster. Aughey GN, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561239, Free PMC Article
    2. Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster. Zhang H, et al. Exp Gerontol, 2010 Nov. PMID 20600782, Free PMC Article
    3. Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2. Wallace HA, et al. G3 (Bethesda), 2015 Mar 9. PMID 25758823, Free PMC Article
    4. Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus. Messina G, et al. BMC Biol, 2022 Aug 3. PMID 35922843, Free PMC Article
    5. H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development. Zhu JY, et al. J Cardiovasc Dev Dis, 2023 Jul 18. PMID 37504562, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mrg15 is a subunit of the Ash1 complex, a stimulator of Ash1 enzymatic activity and a critical regulator of the TrxG protein function of Ash1 in Drosophila.
      Title: Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.
    2. Ash1 HMTase activity is activated by MRG15, a subunit of the identified Ash1 complex, and that this complex, rather than the Ash1 protein alone, is the active form of this H3K36 methyltransferase, both in vitro and in vivo.
      Title: Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.
    3. Mrg15 interacts with Cap-H2 condensin subunit.
      Title: Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15.
    4. Drosophila DmMRG15 gene function is required for female fertility, larval survival and adult life span, and provides reagents that should be useful for further dissecting the role of DmMRG15 in cell proliferation and aging.
      Title: Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of histone methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MORF-related gene 15
    Names
    CG6363-PA
    CG6363-PB
    MRG15-PA
    MRG15-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15276440..15278109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142185.2 → NP_650442.1  MORF-related gene 15, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VF99, Q9Y0I1
      Related
      FBpp0082579, FBtr0083125
      Conserved Domains (2) summary
      pfam05712
      Location:244 → 410
      MRG; MRG
      pfam11717
      Location:22 → 75
      Tudor-knot; RNA binding activity-knot of a chromodomain

    2. NM_001275659.1 → NP_001262588.1  MORF-related gene 15, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ7
      Conserved Domains (2) summary
      pfam05712
      Location:249 → 415
      MRG; MRG
      pfam11717
      Location:22 → 75
      Tudor-knot; RNA binding activity-knot of a chromodomain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHJ7 A0A0B4KHJ7
    Q9Y0I1.1 Q9Y0I1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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