fbl fumble [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fblprovided by FlyBase
Official Full Name: fumbleprovided by FlyBase
Primary source: FLYBASE:FBgn0011205
Locus tag: Dmel_CG5725
See related: AllianceGenome:FB:FBgn0011205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5725; Dmel\CG5725; dPanK; dPANK; dPANK/fbl; dPANK/Fbl; Fbl; FblD; fblMtr4; PANK
Summary: Enables pantothenate kinase activity. Involved in several processes, including cellular response to gamma radiation; locomotor rhythm; and triglyceride homeostasis. Located in cytoplasm; plasma membrane; and spindle. Is expressed in adult head. Used to study pantothenate kinase-associated neurodegeneration. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to several human genes including PANK2 (pantothenate kinase 2) and PANK3 (pantothenate kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20384429..20391913)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20377529..20385013)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Only mitochondria-targeted Fbl or human PanK2 was able to rescue fbl mutation.
Title: Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model.
analysis of dietary rescue of fumble in a Drosophila model for pantothenate kinase-associated neurodegeneration
Title: Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables pantothenate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantothenate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables pantothenate kinase activity	IEA Inferred from Electronic Annotation more info
enables pantothenate kinase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coenzyme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in coenzyme A biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in coenzyme A biosynthetic process	ISA Inferred from Sequence Alignment more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

Names: CG5725-PA; CG5725-PB; CG5725-PC; CG5725-PD; CG5725-PE; CG5725-PF; CG5725-PG; fbl-PA; fbl-PB; fbl-PC; fbl-PD; fbl-PE; fbl-PF; fbl-PG; pantothenate kinase