Slc39a5 solute carrier family 39 (metal ion transporter), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a5provided by MGI
Official Full Name: solute carrier family 39 (metal ion transporter), member 5provided by MGI
Primary source: MGI:MGI:1919336
See related: Ensembl:ENSMUSG00000039878 AllianceGenome:MGI:1919336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zip5; 1810013D05Rik; 2010205A06Rik
Summary: Enables zinc ion transmembrane transporter activity. Involved in zinc ion transmembrane transport. Acts upstream of or within cellular response to zinc ion starvation and positive regulation of mRNA splicing, via spliceosome. Located in basolateral plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in myopia. Orthologous to human SLC39A5 (solute carrier family 39 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in duodenum adult (RPKM 158.7), large intestine adult (RPKM 83.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.55 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128231796..128237145, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128395927..128401276, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC39A5 promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling.
Title: SLC39A5 promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling.
The authors show that Slc39a5-mediated zinc influx induces expression of Glut2 (Glucose Transporter Type 2) via Sirt1 (sirtuin 1)-mediated Pgc-1alpha (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) activation.
Title: The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2.
The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity.
Title: The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity.
ZIP5 is directed to the same subcellular locations as PrP(C) and both proteins are seen to be endocytosed through vesicles decorated with the Rab5 marker protein.
Title: The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer.
miR-328 and miR-193a are expressed in tissues known to regulate Zip5 mRNA translation in response to zinc availability and both are polysome-associated consistent with Zip5 mRNA localization
Title: Regulation of zinc-responsive Slc39a5 (Zip5) translation is mediated by conserved elements in the 3'-untranslated region.
Zip5 mRNA abundance does not change in response to zinc, but the translation of this mRNA was found to be zinc-responsive
Title: Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5).
temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined
Title: Expression and regulation of SLC39A family zinc transporters in the developing mouse intestine.
Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells
Title: The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.
ZIP4 and ZIP5 have roles in the adaptive response to dietary zinc in mice [ZIP5]
Title: The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (6) 1 citation

General gene information

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Markers

Slc39a5 (e-PCR), detects polymorphism
- UniSTS:547344

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion transmembrane transporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to zinc ion starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within zinc ion transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: zinc transporter ZIP5

Names: ZIP-5; solute carrier family 39 member 5; zrt- and Irt-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136237.1 → NP_001129709.1 zinc transporter ZIP5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI413122, AK008448, CA492656

Consensus CDS

CCDS24275.1

UniProtKB/Swiss-Prot

Q9D856, Q9D909

Related

ENSMUSP00000037753.6, ENSMUST00000042666.13

Conserved Domains (1) summary

pfam02535
Location:243 → 499

Zip; ZIP Zinc transporter
NM_028051.3 → NP_082327.2 zinc transporter ZIP5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI413122, AK007473, AK008448

Consensus CDS

CCDS24275.1

UniProtKB/Swiss-Prot

Q9D856, Q9D909

Related

ENSMUSP00000131736.2, ENSMUST00000167859.2

Conserved Domains (1) summary

pfam02535
Location:243 → 499

Zip; ZIP Zinc transporter
NM_028092.3 → NP_082368.1 zinc transporter ZIP5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI413122, AK008448

Consensus CDS

CCDS24275.1

UniProtKB/Swiss-Prot

Q9D856, Q9D909

Conserved Domains (1) summary

pfam02535
Location:243 → 499

Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128231796..128237145 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514172.3 → XP_006514235.1 zinc transporter ZIP5 isoform X1

UniProtKB/Swiss-Prot

Q9D856, Q9D909

Conserved Domains (1) summary

pfam02535
Location:243 → 499

Zip; ZIP Zinc transporter
XM_006514173.3 → XP_006514236.1 zinc transporter ZIP5 isoform X1

UniProtKB/Swiss-Prot

Q9D856, Q9D909

Conserved Domains (1) summary

pfam02535
Location:243 → 499

Zip; ZIP Zinc transporter
XM_011243579.1 → XP_011241881.1 zinc transporter ZIP5 isoform X2

Conserved Domains (1) summary

cl00437
Location:243 → 278

Zip; ZIP Zinc transporter