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    Dhrsx dehydrogenase/reductase X linked [ Mus musculus (house mouse) ]

    Gene ID: 236082, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dhrsxprovided by MGI
    Official Full Name
    dehydrogenase/reductase X linkedprovided by MGI
    Primary source
    MGI:MGI:2181510
    See related
    AllianceGenome:MGI:2181510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pscad; Dhrsxy; D4Ertd296e
    Summary
    Predicted to enable dolichal reductase activity and polyprenol dehydrogenase activity. Predicted to be involved in dolichol biosynthetic process and positive regulation of autophagy. Predicted to be active in extracellular region and lipid droplet. Orthologous to human DHRSX (dehydrogenase/reductase X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Dhrsx in Genome Data Viewer
    Location:
    4 E2; 4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156390105..156410432)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 Unlocalized Scaffold NT_166291.1 (14351..36213)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 11 Neighboring gene predicted gene, 47252 Neighboring gene predicted gene, 54274 Neighboring gene predicted gene, 53226 Neighboring gene predicted gene, 54275

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. Gianfrancesco F, et al. Genome Res, 2001 Dec. PMID 11731500, Free PMC Article
    2. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC170222, MGC170224

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichal reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables polyprenol dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    polyprenol dehydrogenase; dehydrogenase/reductase SDR family member on chromosome X homolog
    Names
    SCAD family protein
    dehydrogenase/reductase (SDR family) X chromosome
    dehydrogenase/reductase SDR family member on chromosome Y
    dolichal reductase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033326.3 → NP_001028498.2  polyprenol dehydrogenase isoform 1

      Status: VALIDATED

      Source sequence(s)
      CAAA01118383, CAAA01125276
      UniProtKB/Swiss-Prot
      B2RRV9, Q3TZW6, Q8VBZ0
      Conserved Domains (2) summary
      cd05327
      Location:43 → 316
      retinol-DH_like_SDR_c_like; retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
      PRK06197
      Location:38 → 324
      PRK06197; short chain dehydrogenase; Provisional

    2. NM_001368261.1 → NP_001355190.1  polyprenol dehydrogenase isoform 2

      Status: VALIDATED

      Source sequence(s)
      CAAA01118383, CAAA01125276
      UniProtKB/Swiss-Prot
      B2RRV9, Q3TZW6, Q8VBZ0

    3. NM_001368262.1 → NP_001355191.1  polyprenol dehydrogenase isoform 3

      Status: VALIDATED

      Source sequence(s)
      CAAA01118383, CAAA01125276
      UniProtKB/Swiss-Prot
      B2RRV9, Q3TZW6, Q8VBZ0

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156390105..156410432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251639.2 → XP_030107499.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X4

      Conserved Domains (1) summary
      cl21454
      Location:1 → 184
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_030251637.2 → XP_030107497.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:1 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_030251638.2 → XP_030107498.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:6 → 192
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_006535904.5 → XP_006535967.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X4

      Conserved Domains (1) summary
      cl21454
      Location:1 → 184
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. XM_006535901.4 → XP_006535964.1  dehydrogenase/reductase SDR family member on chromosome X homolog isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:37 → 246
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBZ0.2 GenPept UniProtKB/Swiss-Prot:Q8VBZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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