Dpp4 dipeptidylpeptidase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpp4provided by MGI
Official Full Name: dipeptidylpeptidase 4provided by MGI
Primary source: MGI:MGI:94919
See related: Ensembl:ENSMUSG00000035000 AllianceGenome:MGI:94919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd26; THAM; Dpp-4
Summary: Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in large intestine adult (RPKM 30.2), small intestine adult (RPKM 11.7) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.3; 2 35.85 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (62160417..62242635, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (62330073..62412315, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion.
Title: Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion.
Dipeptidyl peptidase-4 disturbs adipocyte differentiation via the negative regulation of the glucagon-like peptide-1/adiponectin-cathepsin K axis in mice under chronic stress conditions.
Title: Dipeptidyl peptidase-4 disturbs adipocyte differentiation via the negative regulation of the glucagon-like peptide-1/adiponectin-cathepsin K axis in mice under chronic stress conditions.
Macrophages communicate with mesangial cells through the CXCL12/DPP4 axis in lupus nephritis pathogenesis.
Title: Macrophages communicate with mesangial cells through the CXCL12/DPP4 axis in lupus nephritis pathogenesis.
Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury.
Title: Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury.
Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.
Title: Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.
Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells.
Title: Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells.
Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis.
Title: Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis.
Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
Title: Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
Title: FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.
Title: Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.

Submit: New GeneRIF Correction See all GeneRIFs (121)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DPP4 (e-PCR)
- UniSTS:505438

GDB:207675 (e-PCR)
- UniSTS:156121

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables chemorepellent activity	IEA Inferred from Electronic Annotation more info
enables chemorepellent activity	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables dipeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables dipeptidyl-peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B-1a B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	IEA Inferred from Electronic Annotation more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extracellular matrix disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of natural killer cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within psychomotor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intercellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dipeptidyl peptidase 4

Names: DPP IV; T-cell activation antigen CD26; dipeptidyl peptidase IV; thymocyte-activating molecule

NP_001153015.1

EC 3.4.14.5

NP_034204.1

EC 3.4.14.5

XP_006498754.1

EC 3.4.14.5

XP_006498755.1

EC 3.4.14.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159543.1 → NP_001153015.1 dipeptidyl peptidase 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK085370, AK163085, AL928804

UniProtKB/TrEMBL

Q3TR43

Conserved Domains (3) summary

pfam00930
Location:102 → 472

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

pfam00326
Location:553 → 729

Peptidase_S9; Prolyl oligopeptidase family

pfam18811
Location:36 → 56

DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
NM_010074.3 → NP_034204.1 dipeptidyl peptidase 4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK085370, AK163085, AL928804

Consensus CDS

CCDS16065.1

UniProtKB/Swiss-Prot

P28843, Q3U514

UniProtKB/TrEMBL

Q3TR43

Related

ENSMUSP00000044050.8, ENSMUST00000047812.8

Conserved Domains (3) summary

COG1506
Location:392 → 758

DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]

pfam00326
Location:553 → 757

Peptidase_S9; Prolyl oligopeptidase family

pfam00930
Location:102 → 472

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

62160417..62242635 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498691.5 → XP_006498754.1 dipeptidyl peptidase 4 isoform X2

UniProtKB/TrEMBL

Q3TR43

Conserved Domains (3) summary

pfam00930
Location:102 → 472

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

pfam18811
Location:37 → 56

DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region

cl21494
Location:553 → 678

Abhydrolase; alpha/beta hydrolases
XM_006498692.5 → XP_006498755.1 dipeptidyl peptidase 4 isoform X1

UniProtKB/TrEMBL

Q3TR43

Conserved Domains (3) summary

pfam00930
Location:102 → 472

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

pfam18811
Location:37 → 56

DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region

cl21494
Location:553 → 679

Abhydrolase; alpha/beta hydrolases