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    Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 [ Mus musculus (house mouse) ]

    Gene ID: 56448, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp2d22provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily d, polypeptide 22provided by MGI
    Primary source
    MGI:MGI:1929474
    See related
    Ensembl:ENSMUSG00000061740 AllianceGenome:MGI:1929474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2D22
    Summary
    Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; dopamine biosynthetic process; and oxidative demethylation. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 124.5), duodenum adult (RPKM 32.3) and 17 other tissues See more
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    Genomic context

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    See Cyp2d22 in Genome Data Viewer
    Location:
    15 E1; 15 38.57 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82254728..82264461, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82370527..82380260, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene single-pass membrane protein with aspartate rich tail 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82192158-82192359 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 11 Neighboring gene microRNA 7684 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Singh S, et al. Rejuvenation Res, 2009 Jun. PMID 19594327
    2. Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells. Blume N, et al. Arch Biochem Biophys, 2000 Sep 15. PMID 11032406
    3. Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice. Long N, et al. J Toxicol Sci, 2019. PMID 30944282
    4. Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion. Yasukochi Y, et al. Genome Biol Evol, 2015 Mar 25. PMID 25808902, Free PMC Article
    5. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Choudhary D, et al. Arch Biochem Biophys, 2003 Jun 1. PMID 12745259

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Its mRNA expression is decreased by the high level of MRSA, but the low level of MRSA increased its expression.
      Title: Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.
    2. CYP2D22 is expressed in mouse striatum and has a possible role in the MPTP-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection
      Title: The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Potential readthrough

    Included gene: Cyp2d9

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anandamide 11,12 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 14,15 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 8,9 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aromatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables progesterone 21-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxidative demethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in serotonin biosynthetic process from tryptophan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily d, polypeptide 22
    Names
    cytochrome P450, 2d22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163472.1 → NP_001156944.1  cytochrome P450, family 2, subfamily d, polypeptide 22

      See identical proteins and their annotated locations for NP_001156944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC104325, AC113593, AW494268
      Consensus CDS
      CCDS37159.1
      UniProtKB/TrEMBL
      Q91W87, Q9JKY7
      Related
      ENSMUSP00000023083.8, ENSMUST00000023083.9
      Conserved Domains (1) summary
      pfam00067
      Location:37 → 496
      p450; Cytochrome P450

    2. NM_019823.4 → NP_062797.3  cytochrome P450, family 2, subfamily d, polypeptide 22

      See identical proteins and their annotated locations for NP_062797.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC104325, AC113593, AK090296, AW494268, BX520002, BY297294
      Consensus CDS
      CCDS37159.1
      UniProtKB/TrEMBL
      Q91W87, Q9JKY7
      Conserved Domains (1) summary
      pfam00067
      Location:37 → 496
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82254728..82264461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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