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    Tnnt1 troponin T1, skeletal, slow [ Mus musculus (house mouse) ]

    Gene ID: 21955, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tnnt1provided by MGI
    Official Full Name
    troponin T1, skeletal, slowprovided by MGI
    Primary source
    MGI:MGI:1333868
    See related
    Ensembl:ENSMUSG00000064179 AllianceGenome:MGI:1333868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tnt; sTnT; ssTnT
    Summary
    This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction. In humans, mutations in this gene are associated with nemaline myopathy type 5. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in limb E14.5 (RPKM 26.9), CNS E11.5 (RPKM 6.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnnt1 in Genome Data Viewer
    Location:
    7 A1; 7 2.6 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4507568..4518974, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4504569..4515975, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1 Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4461475-4461662 Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3 Neighboring gene synaptotagmin V

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tropomyosin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables troponin T binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables troponin T binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables troponin T binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in slow-twitch skeletal muscle fiber contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in slow-twitch skeletal muscle fiber contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in slow-twitch skeletal muscle fiber contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transition between fast and slow fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of troponin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    troponin T, slow skeletal muscle
    Names
    skeletal muscle slow-twitch TnT

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277903.1 → NP_001264832.1  troponin T, slow skeletal muscle isoform 1

      See identical proteins and their annotated locations for NP_001264832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC161218
      Consensus CDS
      CCDS71880.1
      UniProtKB/Swiss-Prot
      B7ZNV5, B7ZNV6, O88346, O88795, Q9QUP7
      UniProtKB/TrEMBL
      B7ZNV4
      Related
      ENSMUSP00000104228.3, ENSMUST00000108587.9
      Conserved Domains (1) summary
      pfam00992
      Location:69 → 205
      Troponin
    2. NM_001277904.1 → NP_001264833.1  troponin T, slow skeletal muscle isoform 3

      See identical proteins and their annotated locations for NP_001264833.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3, also known as low Mr isoform), compared to isoform 1.
      Source sequence(s)
      AC161218
      Consensus CDS
      CCDS71879.1
      UniProtKB/TrEMBL
      B7ZNV4
      Related
      ENSMUSP00000129626.2, ENSMUST00000163710.8
      Conserved Domains (1) summary
      pfam00992
      Location:57 → 193
      Troponin
    3. NM_001360154.1 → NP_001347083.1  troponin T, slow skeletal muscle isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC161218
      UniProtKB/TrEMBL
      B7ZNV4
      Related
      ENSMUSP00000128476.2, ENSMUST00000166268.8
      Conserved Domains (1) summary
      pfam00992
      Location:58 → 194
      Troponin
    4. NM_001417401.1 → NP_001404330.1  troponin T, slow skeletal muscle isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC161218
      UniProtKB/TrEMBL
      B7ZNV4
    5. NM_001417402.1 → NP_001404331.1  troponin T, slow skeletal muscle isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC161218
    6. NM_011618.2 → NP_035748.1  troponin T, slow skeletal muscle isoform 2

      See identical proteins and their annotated locations for NP_035748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2, also known as high Mr isoform 2), compared to isoform 1.
      Source sequence(s)
      AK160226
      Consensus CDS
      CCDS51973.1
      UniProtKB/TrEMBL
      B7ZNV4, Q3TVB8
      Related
      ENSMUSP00000071704.7, ENSMUST00000071798.13
      Conserved Domains (1) summary
      pfam00992
      Location:68 → 204
      Troponin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4507568..4518974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322114.2 → XP_017177603.1  troponin T, slow skeletal muscle isoform X4

      UniProtKB/TrEMBL
      B7ZNV4
      Conserved Domains (1) summary
      pfam00992
      Location:97 → 233
      Troponin
    2. XM_017322113.2 → XP_017177602.1  troponin T, slow skeletal muscle isoform X3

      UniProtKB/TrEMBL
      B7ZNV4
      Conserved Domains (1) summary
      pfam00992
      Location:98 → 234
      Troponin
    3. XM_017322112.2 → XP_017177601.1  troponin T, slow skeletal muscle isoform X2

      UniProtKB/TrEMBL
      B7ZNV4
      Conserved Domains (1) summary
      pfam00992
      Location:108 → 244
      Troponin
    4. XM_017322111.2 → XP_017177600.1  troponin T, slow skeletal muscle isoform X1

      UniProtKB/TrEMBL
      B7ZNV4
      Conserved Domains (1) summary
      pfam00992
      Location:109 → 245
      Troponin
    5. XM_011250478.3 → XP_011248780.1  troponin T, slow skeletal muscle isoform X6

      Conserved Domains (1) summary
      pfam00992
      Location:88 → 224
      Troponin
    6. XM_011250477.3 → XP_011248779.1  troponin T, slow skeletal muscle isoform X5

      Conserved Domains (1) summary
      pfam00992
      Location:89 → 225
      Troponin