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    Taf7 TATA-box binding protein associated factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 24074, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taf7provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 7provided by MGI
    Primary source
    MGI:MGI:1346348
    See related
    Ensembl:ENSMUSG00000051316 AllianceGenome:MGI:1346348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    55kDa; Taf2f; TAFII55
    Summary
    Enables histone acetyltransferase binding activity. Acts upstream of or within estrogen receptor signaling pathway; regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Located in cytoplasm and male germ cell nucleus. Part of transcription factor TFIID complex. Is expressed in blastocyst; brain; genitourinary system; and tail. Orthologous to human TAF7 (TATA-box binding protein associated factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 17.1), CNS E11.5 (RPKM 5.7) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Taf7 in Genome Data Viewer
    Location:
    18 B3; 18 19.54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37773544..37777257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37640491..37644204, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene STARR-seq mESC enhancer starr_44310 Neighboring gene STARR-seq mESC enhancer starr_44311 Neighboring gene protocadherin beta 22 Neighboring gene STARR-seq mESC enhancer starr_44313 Neighboring gene STARR-seq mESC enhancer starr_44314 Neighboring gene STARR-positive B cell enhancer ABC_E4245 Neighboring gene RIKEN cDNA 3222401L13 gene Neighboring gene solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2 Neighboring gene protein UXT pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables H3K27me3 modified histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to H3K27me3 modified histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-TEFb complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-TEFb complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables TFIIH-class transcription factor complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TFIIH-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear thyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear vitamin D receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear vitamin D receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA polymerase II preinitiation complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MHC class I biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of MHC class I biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MHC class II biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of MHC class II biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 7
    Names
    RNA polymerase II TBP-associated factor subunit F
    TAF(II)55
    TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55 kDa
    TAFII-55
    TATA box binding protein (TBP) associated factor, RNA polymerase II, F, 55 kDa
    transcription initiation factor TFIID 55 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175770.4NP_786964.1  transcription initiation factor TFIID subunit 7

      See identical proteins and their annotated locations for NP_786964.1

      Status: VALIDATED

      Source sequence(s)
      AC020971, AK076362, DV656353
      Consensus CDS
      CCDS29189.1
      UniProtKB/Swiss-Prot
      Q9R1C0
      UniProtKB/TrEMBL
      Q8BPH4
      Related
      ENSMUSP00000065645.5, ENSMUST00000066272.6
      Conserved Domains (1) summary
      pfam04658
      Location:12177
      TAFII55_N; TAFII55 protein conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      37773544..37777257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)