Nsun2 NOL1/NOP2/Sun domain family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nsun2provided by MGI
Official Full Name: NOL1/NOP2/Sun domain family member 2provided by MGI
Primary source: MGI:MGI:107252
See related: Ensembl:ENSMUSG00000021595 AllianceGenome:MGI:107252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Misu; D13Wsu123e
Summary: Enables mRNA (cytidine-5-)-methyltransferase activity and tRNA (cytidine-5-)-methyltransferase activity. Involved in several processes, including RNA processing; meiotic cell cycle checkpoint signaling; and tRNA stabilization. Acts upstream of or within in utero embryonic development. Located in chromatoid body. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 24.0), testis adult (RPKM 23.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B3; 13 35.55 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (69760135..69783899)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (69612016..69635780)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NSUN2 is critical for mouse oocyte meiosis and early embryonic development.
Title: NSUN2 is critical for mouse oocyte meiosis and early embryonic development.
NSUN2 mediates distinct pathways to regulate enterovirus 71 replication.
Title: NSUN2 mediates distinct pathways to regulate enterovirus 71 replication.
NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.
Title: NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.
NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication.
Title: NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication.
Long noncoding RNA DIAPH2-AS1 promotes neural invasion of gastric cancer via stabilizing NSUN2 to enhance the m5C modification of NTN1.
Title: Long noncoding RNA DIAPH2-AS1 promotes neural invasion of gastric cancer via stabilizing NSUN2 to enhance the m5C modification of NTN1.
NSUN2-mediated M[5]c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Title: NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis.
Title: Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis.
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
Title: RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.
Title: Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.
Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency.
Title: Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Gene trapped (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI463178 (e-PCR)
- UniSTS:208955

RH125669 (e-PCR)
- UniSTS:141969

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA (cytidine-5-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA (cytidine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (cytidine-5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (cytidine-5-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA (cytidine-5-)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA (cytidine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hair follicle maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatoid body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA cytosine C(5)-methyltransferase NSUN2

Names: Myc-induced SUN domain containing protein; NOL1/NOP2/Sun domain family 2; mRNA cytosine C(5)-methyltransferase; myc-induced SUN domain-containing protein; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase

NP_663329.3

EC 2.1.1.203

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.