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    Stk16 serine/threonine kinase 16 [ Mus musculus (house mouse) ]

    Gene ID: 20872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stk16provided by MGI
    Official Full Name
    serine/threonine kinase 16provided by MGI
    Primary source
    MGI:MGI:1313271
    See related
    Ensembl:ENSMUSG00000026201 AllianceGenome:MGI:1313271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EDPK; Krct; MPSK; PKL12; TSF-1
    Summary
    Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in Golgi apparatus and Golgi-associated vesicle. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural retina; and respiratory system. Orthologous to human STK16 (serine/threonine kinase 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 26.8), kidney adult (RPKM 26.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stk16 in Genome Data Viewer
    Location:
    1 C4; 1 38.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75187463..75192250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75210819..75215606)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321 Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like Neighboring gene STARR-positive B cell enhancer ABC_E3282 Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene tubulin, alpha 4A Neighboring gene STARR-seq mESC enhancer starr_01353 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo. Kurioka K, et al. Biochim Biophys Acta, 1998 Dec 22. PMID 9878782
    2. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. Berson AE, et al. Biochem Biophys Res Commun, 1999 Jun 16. PMID 10364453
    3. Mammary gland development, reproductive history, and breast cancer risk. Chodosh LA, et al. Cancer Res, 1999 Apr 1. PMID 10197594
    4. Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling. Ligos JM, et al. J Biol Chem, 2002 Feb 22. PMID 11741987
    5. Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation. Guinea B, et al. Exp Cell Res, 2006 Jan 15. PMID 16310770

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 16
    Names
    TGF-beta-stimulated factor 1
    embryo-derived protein kinase
    kinase related to cerevisiae and thaliana
    myristoylated and palmitoylated serine/threonine-protein kinase
    tyrosine-protein kinase STK16
    NP_001264921.1
    NP_035624.3
    XP_006496524.1
    XP_006496525.1
    XP_030108374.1
    XP_030108376.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277992.1 → NP_001264921.1  serine/threonine-protein kinase 16

      See identical proteins and their annotated locations for NP_001264921.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK030404, BY198855, CX200029
      Consensus CDS
      CCDS15067.1
      UniProtKB/Swiss-Prot
      O88697, Q3UEG5, Q9JMJ0, Q9JMJ1, Q9QX00
      UniProtKB/TrEMBL
      Q8BSV9
      Conserved Domains (1) summary
      cd13986
      Location:19 → 295
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    2. NM_011494.5 → NP_035624.3  serine/threonine-protein kinase 16

      See identical proteins and their annotated locations for NP_035624.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK030404, AK149539, BY237826
      Consensus CDS
      CCDS15067.1
      UniProtKB/Swiss-Prot
      O88697, Q3UEG5, Q9JMJ0, Q9JMJ1, Q9QX00
      UniProtKB/TrEMBL
      Q8BSV9
      Related
      ENSMUSP00000027401.5, ENSMUST00000027401.11
      Conserved Domains (1) summary
      cd13986
      Location:19 → 295
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    RNA

    1. NR_102731.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA183397, AC166150, AK030404, BY237826

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75187463..75192250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496462.2 → XP_006496525.1  serine/threonine-protein kinase 16 isoform X2

      See identical proteins and their annotated locations for XP_006496525.1

      UniProtKB/TrEMBL
      Q8BSV9
      Conserved Domains (1) summary
      cd13986
      Location:19 → 263
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    2. XM_006496461.3 → XP_006496524.1  serine/threonine-protein kinase 16 isoform X1

      See identical proteins and their annotated locations for XP_006496524.1

      UniProtKB/Swiss-Prot
      O88697, Q3UEG5, Q9JMJ0, Q9JMJ1, Q9QX00
      UniProtKB/TrEMBL
      Q8BSV9
      Conserved Domains (1) summary
      cd13986
      Location:19 → 295
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    3. XM_030252516.2 → XP_030108376.1  serine/threonine-protein kinase 16 isoform X2

      UniProtKB/TrEMBL
      Q8BSV9
      Conserved Domains (1) summary
      cd13986
      Location:19 → 263
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    4. XM_030252514.2 → XP_030108374.1  serine/threonine-protein kinase 16 isoform X2

      UniProtKB/TrEMBL
      Q8BSV9
      Conserved Domains (1) summary
      cd13986
      Location:19 → 263
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    RNA

    1. XR_004941329.1 RNA Sequence

    2. XR_004941328.1 RNA Sequence

      Related
      ENSMUST00000191108.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88697.3 GenPept UniProtKB/Swiss-Prot:O88697

    Gene LinkOut

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