Vezf1 vascular endothelial zinc finger 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vezf1provided by MGI
Official Full Name: vascular endothelial zinc finger 1provided by MGI
Primary source: MGI:MGI:1313291
See related: Ensembl:ENSMUSG00000018377 AllianceGenome:MGI:1313291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: db1
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within angiogenesis and endothelial cell development. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and liver. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 16.4), CNS E14 (RPKM 15.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 52.4 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87959084..87975555)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (88068199..88084729)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vezf1 regulates cardiac structure and contractile function.
Title: Vezf1 regulates cardiac structure and contractile function.
Nuclear RhoB-GTP controls expression of distinct gene sets in each endothelial lineage by regulating VEZF1-mediated transcription.
Title: RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription.
find examples of genes in which Vezf1 binding sites are located near cassette exons, and in which loss of Vezf1 leads to a change in the relative abundance of alternatively spliced messages
Title: Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.
Suggest that Vezf1 is involved in early differentiation processes of the vasculature by regulating cell differentiation, proliferation, and ECM distribution and deposition.
Title: Targeted Vezf1-null mutation impairs vascular structure formation during embryonic stem cell differentiation.
Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.
Title: Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.
In the developing embryo, Vezf1 is expressed in the yolk sac mesoderm and the endothelium of the developing vasculature and, in addition, in mesodermal and neuronal tissues.
Title: Dosage-dependent requirement for mouse Vezf1 in vascular system development.
Vezf1 is involved in the regulation of angiogenesis, at least in part, through the expression of stathmin/OP18 in endothelial cells.
Title: Vascular endothelial zinc finger 1 is involved in the regulation of angiogenesis: possible contribution of stathmin/OP18 as a downstream target gene.
vascular endothelial zinc finger-1 interacts with p68RacGAP and has a role in endothelial cell capillary formation
Title: p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI848691 (e-PCR)
- UniSTS:180286

AW046909 (e-PCR)
- UniSTS:180288

D11Mit196.1 (e-PCR), detects polymorphism
- UniSTS:126394

Vezf1 (e-PCR), detects polymorphism
- UniSTS:496840

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vascular endothelial zinc finger 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402868.1 → NP_001389797.1 vascular endothelial zinc finger 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL593853
NM_001402869.1 → NP_001389798.1 vascular endothelial zinc finger 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL593853
NM_001402870.1 → NP_001389799.1 vascular endothelial zinc finger 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL593853
NM_001402871.1 → NP_001389800.1 vascular endothelial zinc finger 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL593853
NM_001402872.1 → NP_001389801.1 vascular endothelial zinc finger 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL593853

Related

ENSMUSP00000114394.2, ENSMUST00000143052.2
NM_001402873.1 → NP_001389802.1 vascular endothelial zinc finger 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL593853
NM_001402874.1 → NP_001389803.1 vascular endothelial zinc finger 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL593853
NM_016686.5 → NP_057895.2 vascular endothelial zinc finger 1 isoform 1

See identical proteins and their annotated locations for NP_057895.2

Status: VALIDATED

Source sequence(s)

AL593853

Consensus CDS

CCDS48880.1

UniProtKB/TrEMBL

Q5SXC4

Related

ENSMUSP00000018521.5, ENSMUST00000018521.11

Conserved Domains (2) summary

sd00017
Location:176 → 196

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:188 → 213

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

87959084..87975555

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156628.1 → XP_036012521.1 vascular endothelial zinc finger 1 isoform X4

Conserved Domains (2) summary

COG5189
Location:230 → 287

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:208 → 228

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036156626.1 → XP_036012519.1 vascular endothelial zinc finger 1 isoform X1

Conserved Domains (4) summary

PRK12799
Location:415 → 532

motB; flagellar motor protein MotB; Reviewed

COG5189
Location:230 → 287

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:208 → 228

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:206 → 228

zf-C2H2; Zinc finger, C2H2 type
XM_036156629.1 → XP_036012522.1 vascular endothelial zinc finger 1 isoform X5

Conserved Domains (2) summary

COG5189
Location:230 → 287

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:208 → 228

ZF_C2H2; C2H2 Zn finger [structural motif]