Selenot selenoprotein T [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Selenotprovided by MGI
Official Full Name: selenoprotein Tprovided by MGI
Primary source: MGI:MGI:1916477
See related: Ensembl:ENSMUSG00000075700 AllianceGenome:MGI:1916477
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Selt; 2810407C02Rik; 5730408P04Rik
Summary: This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in kidney adult (RPKM 32.3), placenta adult (RPKM 31.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 28.61 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (58484057..58500965)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (58576636..58593544)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SELENOT Deficiency in the Mouse Brain Impacts Catecholaminergic Neuron Density: An Immunohistochemical, in situ Hybridization and 3D Light-Sheet Imaging Study.
Title: SELENOT Deficiency in the Mouse Brain Impacts Catecholaminergic Neuron Density: An Immunohistochemical, in situ Hybridization and 3D Light-Sheet Imaging Study.
miR-431-5p regulates apoptosis of cardiomyocytes after acute myocardial infarction via targeting selenoprotein T.
Title: miR-431-5p regulates apoptosis of cardiomyocytes after acute myocardial infarction via targeting selenoprotein T.
Hepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism.
Title: Hepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism.
Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis.
Title: Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis.
Selenoprotein T is a novel oligosaccharyltransferase subunit that regulates unfolded protein response signaling and ASTH secretion.
Title: Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion.
SelT exerts a neuroprotective role which is essential during brain development, and that its loss impairs mice behavior.
Title: Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice.
The SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD.
Title: Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease.
Data suggest SelT is expressed in pancreatic beta- and delta-cells; inactivation of SelT in beta-cells leads to glucose intolerance via impaired glucose homeostasis and PACAP (pituitary adenylate cyclase-activating polypeptide) insulinotropic effect.
Title: The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance.
Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT.
Title: Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235842

RH125340 (e-PCR)
- UniSTS:162162

NoName (e-PCR)
- UniSTS:234693

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables thioredoxin-disulfide reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin-disulfide reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables thioredoxin-disulfide reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: thioredoxin reductase-like selenoprotein T

Names: thioredoxin reductase-like enzyme

NP_001035486.2

EC 1.8.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040396.3 → NP_001035486.2 thioredoxin reductase-like selenoprotein T precursor

See identical proteins and their annotated locations for NP_001035486.2

Status: REVIEWED

Source sequence(s)

AA155383, AK013022, AK047958, BF660234, BY123391

Consensus CDS

CCDS38437.1

UniProtKB/Swiss-Prot

A2RTC6, P62342, Q8CHV4

Related

ENSMUSP00000103557.3, ENSMUST00000107924.3

Conserved Domains (1) summary

TIGR02174
Location:41 → 179

CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

58484057..58500965

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_026997.1: Suppressed sequence

Description

NM_026997.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.