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    Usp31 ubiquitin specific peptidase 31 [ Mus musculus (house mouse) ]

    Gene ID: 76179, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Usp31provided by MGI
    Official Full Name
    ubiquitin specific peptidase 31provided by MGI
    Primary source
    MGI:MGI:1923429
    See related
    Ensembl:ENSMUSG00000063317 AllianceGenome:MGI:1923429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1203; 6330567E21Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be located in nucleus. Orthologous to human USP31 (ubiquitin specific peptidase 31). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.5), cortex adult (RPKM 6.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Usp31 in Genome Data Viewer
    Location:
    7 F2; 7 65.07 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121241244..121306683, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121642021..121707461, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 2 Neighboring gene RIKEN cDNA 4933432K03 gene Neighboring gene RIKEN cDNA 1700025J12 gene Neighboring gene STARR-positive B cell enhancer ABC_E10470 Neighboring gene STARR-positive B cell enhancer ABC_E6594 Neighboring gene STARR-positive B cell enhancer ABC_E8205 Neighboring gene STARR-seq mESC enhancer starr_20066 Neighboring gene sodium channel, nonvoltage-gated 1 gamma Neighboring gene STARR-seq mESC enhancer starr_20067 Neighboring gene predicted gene, 36848 Neighboring gene STARR-seq mESC enhancer starr_20068 Neighboring gene sodium channel, nonvoltage-gated 1 beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 31
    Names
    ubiquitin specific protease 31
    NP_001028345.1
    XP_006508359.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033173.2 → NP_001028345.1  ubiquitin carboxyl-terminal hydrolase 31

      Status: VALIDATED

      Source sequence(s)
      AC134870
      Consensus CDS
      CCDS52386.1
      UniProtKB/TrEMBL
      E9Q6Y8
      Related
      ENSMUSP00000040037.7, ENSMUST00000046929.7
      Conserved Domains (2) summary
      cd02674
      Location:589 → 756
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:124 → 329
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      121241244..121306683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508296.5 → XP_006508359.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

      Conserved Domains (1) summary
      COG5560
      Location:121 → 664
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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