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    Dennd1c DENN domain containing 1C [ Mus musculus (house mouse) ]

    Gene ID: 70785, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dennd1cprovided by MGI
    Official Full Name
    DENN domain containing 1Cprovided by MGI
    Primary source
    MGI:MGI:1918035
    See related
    Ensembl:ENSMUSG00000002668 AllianceGenome:MGI:1918035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4432409M07Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in endocytic recycling and endocytosis. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytosol and intracellular membrane-bounded organelle. Orthologous to human DENND1C (DENN domain containing 1C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 32.6), spleen adult (RPKM 31.1) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dennd1c in Genome Data Viewer
    Location:
    17 D; 17 29.65 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57373051..57385518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57066051..57078529, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Neighboring gene STARR-positive B cell enhancer ABC_E3211 Neighboring gene crumbs family member 3 Neighboring gene tubulin, beta 4A class IVA Neighboring gene predicted gene 11110 Neighboring gene predicted gene, 46589

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30613

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 1C
    Names
    DENN/MADD domain containing 1C
    connecdenn 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384107.1 → NP_001371036.1  DENN domain-containing protein 1C isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (3) summary
      smart00801
      Location:331 → 397
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 299
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:13 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. NM_001384108.1 → NP_001371037.1  DENN domain-containing protein 1C isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (3) summary
      smart00801
      Location:330 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 299
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:13 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. NM_001384109.1 → NP_001371038.1  DENN domain-containing protein 1C isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (3) summary
      smart00801
      Location:330 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 299
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:13 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. NM_001384110.1 → NP_001371039.1  DENN domain-containing protein 1C isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (3) summary
      smart00801
      Location:325 → 391
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 293
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:13 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    5. NM_001384111.1 → NP_001371040.1  DENN domain-containing protein 1C isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (2) summary
      smart00799
      Location:91 → 293
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:13 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    6. NM_153551.2 → NP_705779.1  DENN domain-containing protein 1C isoform 1

      See identical proteins and their annotated locations for NP_705779.1

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Consensus CDS
      CCDS37669.1
      UniProtKB/Swiss-Prot
      Q8CFK6, Q9CXF1
      Related
      ENSMUSP00000011623.8, ENSMUST00000011623.9
      Conserved Domains (3) summary
      smart00801
      Location:325 → 391
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 293
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:13 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57373051..57385518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524901.3 → XP_006524964.1  DENN domain-containing protein 1C isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:331 → 397
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:91 → 299
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:13 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. XM_006524899.4 → XP_006524962.1  DENN domain-containing protein 1C isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:330 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:90 → 298
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:12 → 86
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    3. XM_011246601.3 → XP_011244903.1  DENN domain-containing protein 1C isoform X3

      Conserved Domains (3) summary
      smart00801
      Location:284 → 350
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:44 → 252
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:16 → 40
      uDENN; uDENN domain

    RNA

    1. XR_003952178.2 RNA Sequence

    2. XR_003952179.2 RNA Sequence

      Related
      ENSMUST00000233564.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFK6.1 GenPept UniProtKB/Swiss-Prot:Q8CFK6

    Gene LinkOut

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