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    Cracd capping protein inhibiting regulator of actin [ Mus musculus (house mouse) ]

    Gene ID: 320827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cracdprovided by MGI
    Official Full Name
    capping protein inhibiting regulator of actinprovided by MGI
    Primary source
    MGI:MGI:2444817
    See related
    Ensembl:ENSMUSG00000036377 AllianceGenome:MGI:2444817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crad; Gm10430; mKIAA1211; 2810489J07Rik; 4930529A19Rik; 4931405B09Rik; C530008M17Rik
    Summary
    Involved in maintenance of gastrointestinal epithelium. Predicted to be located in cytosol. Is expressed in several structures, including gut; heart and pericardium; nervous system; skin; and testis. Orthologous to human CRACD (capping protein inhibiting regulator of actin dynamics). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 47.4), CNS E18 (RPKM 17.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cracd in Genome Data Viewer
    Location:
    5 C3.3; 5 41.34 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76803225..77021393)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76657629..76873554)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1053 Neighboring gene exocyst complex component 1 Neighboring gene centrosomal protein 135 Neighboring gene predicted gene, 57768 Neighboring gene ribosomal protein L23a pseudogene Neighboring gene predicted gene, 34369 Neighboring gene STARR-seq mESC enhancer starr_13449 Neighboring gene STARR-seq mESC enhancer starr_13451 Neighboring gene predicted gene, 52818 Neighboring gene STARR-seq mESC enhancer starr_13452 Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma. Kim B, et al. Cell Rep, 2024 Jun 25. PMID 38796854, Free PMC Article
    2. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. Snider PL, et al. J Cardiovasc Dev Dis, 2019 Jun 22. PMID 31234534, Free PMC Article
    3. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Jung YS, et al. Nat Cell Biol, 2018 Nov. PMID 30361697, Free PMC Article
    4. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
    5. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma.
      Title: CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA1211

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of gastrointestinal epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of gastrointestinal epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of barbed-end actin filament capping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    capping protein-inhibiting regulator of actin dynamics
    Names
    cancer-related regulator of actin dynamics
    capping protein inhibiting regulator of actin dynamics

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163793.2 → NP_001157265.1  capping protein-inhibiting regulator of actin dynamics isoform 2

      See identical proteins and their annotated locations for NP_001157265.1

      Status: VALIDATED

      Source sequence(s)
      AC166328
      Consensus CDS
      CCDS51526.1
      UniProtKB/TrEMBL
      A0A5F8MPP1
      Related
      ENSMUSP00000113796.3, ENSMUST00000120639.9
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1267
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    2. NM_001408677.1 → NP_001395606.1  capping protein-inhibiting regulator of actin dynamics isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124978, AC127332, AC166328
      UniProtKB/TrEMBL
      A0A5F8MPP1

    3. NM_001408678.1 → NP_001395607.1  capping protein-inhibiting regulator of actin dynamics isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124978, AC127332, AC166328
      UniProtKB/TrEMBL
      A0A5F8MPP1

    4. NM_001408679.1 → NP_001395608.1  capping protein-inhibiting regulator of actin dynamics isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124978, AC166328
      UniProtKB/TrEMBL
      D3YTS2

    5. NM_001408680.1 → NP_001395609.1  capping protein-inhibiting regulator of actin dynamics isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC166328
      UniProtKB/TrEMBL
      D3YTS2
      Related
      ENSMUSP00000113485.2, ENSMUST00000120818.8

    6. NM_177272.3 → NP_796246.2  capping protein-inhibiting regulator of actin dynamics isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124978, AC127332, AC166328
      UniProtKB/Swiss-Prot
      E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
      UniProtKB/TrEMBL
      A0A5F8MPP1
      Related
      ENSMUSP00000113947.2, ENSMUST00000121160.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      76803225..77021393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320926.3 → XP_017176415.1  capping protein-inhibiting regulator of actin dynamics isoform X6

      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1270
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    2. XM_006535007.4 → XP_006535070.1  capping protein-inhibiting regulator of actin dynamics isoform X6

      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1270
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    3. XM_006535004.4 → XP_006535067.1  capping protein-inhibiting regulator of actin dynamics isoform X5

      See identical proteins and their annotated locations for XP_006535067.1

      UniProtKB/Swiss-Prot
      E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1270
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    4. XM_006535011.4 → XP_006535074.1  capping protein-inhibiting regulator of actin dynamics isoform X7

      See identical proteins and their annotated locations for XP_006535074.1

      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:898 → 1212
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:636 → 1048
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:1 → 114
      DUF4592; Domain of unknown function (DUF4592)

    5. XM_030254581.2 → XP_030110441.1  capping protein-inhibiting regulator of actin dynamics isoform X5

      UniProtKB/Swiss-Prot
      E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1270
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    6. XM_030254580.1 → XP_030110440.1  capping protein-inhibiting regulator of actin dynamics isoform X5

      UniProtKB/Swiss-Prot
      E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1270
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    7. XM_011249480.1 → XP_011247782.1  capping protein-inhibiting regulator of actin dynamics isoform X1

      See identical proteins and their annotated locations for XP_011247782.1

      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1267
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    8. XM_011249481.1 → XP_011247783.1  capping protein-inhibiting regulator of actin dynamics isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (2) summary
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    9. XM_030254579.1 → XP_030110439.1  capping protein-inhibiting regulator of actin dynamics isoform X3

      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1120
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    10. XM_011249482.4 → XP_011247784.1  capping protein-inhibiting regulator of actin dynamics isoform X5

      See identical proteins and their annotated locations for XP_011247784.1

      UniProtKB/Swiss-Prot
      E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1270
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    11. XM_006535008.2 → XP_006535071.1  capping protein-inhibiting regulator of actin dynamics isoform X5

      See identical proteins and their annotated locations for XP_006535071.1

      UniProtKB/Swiss-Prot
      E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:956 → 1270
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:694 → 1106
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:45 → 172
      DUF4592; Domain of unknown function (DUF4592)

    12. XM_006535002.5 → XP_006535065.1  capping protein-inhibiting regulator of actin dynamics isoform X4

      UniProtKB/TrEMBL
      A0A5F8MPP1
      Conserved Domains (3) summary
      PTZ00449
      Location:962 → 1276
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:700 → 1112
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15262
      Location:51 → 178
      DUF4592; Domain of unknown function (DUF4592)

    RNA

    1. XR_004942527.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027611.2: Suppressed sequence

      Description
      NM_027611.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PR69.4 GenPept UniProtKB/Swiss-Prot:Q5PR69

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