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    Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 20511, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc1a2provided by MGI
    Official Full Name
    solute carrier family 1 (glial high affinity glutamate transporter), member 2provided by MGI
    Primary source
    MGI:MGI:101931
    See related
    Ensembl:ENSMUSG00000005089 AllianceGenome:MGI:101931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik
    Summary
    Enables cysteine transmembrane transporter activity; high-affinity L-glutamate transmembrane transporter activity; and monoatomic anion transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; monoatomic anion transmembrane transport; and positive regulation of D-glucose import. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 172.0), frontal lobe adult (RPKM 137.5) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc1a2 in Genome Data Viewer
    Location:
    2 E2; 2 54.13 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102488584..102621129)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102658239..102790784)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene four jointed box 1 Neighboring gene STARR-seq mESC enhancer starr_05255 Neighboring gene STARR-seq mESC enhancer starr_05256 Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene STARR-seq mESC enhancer starr_05257 Neighboring gene STARR-seq mESC enhancer starr_05258 Neighboring gene predicted gene, 57687 Neighboring gene STARR-positive B cell enhancer ABC_E2631 Neighboring gene predicted gene 13872 Neighboring gene STARR-positive B cell enhancer mm9_chr2:102635439-102635740 Neighboring gene STARR-seq mESC enhancer starr_05259 Neighboring gene CD44 antigen Neighboring gene STARR-positive B cell enhancer ABC_E5950 Neighboring gene STARR-positive B cell enhancer ABC_E3387 Neighboring gene STARR-seq mESC enhancer starr_05260 Neighboring gene STARR-seq mESC enhancer starr_05261 Neighboring gene STARR-seq mESC enhancer starr_05262 Neighboring gene predicted gene, 23731 Neighboring gene STARR-positive B cell enhancer ABC_E9522 Neighboring gene STARR-positive B cell enhancer ABC_E2632 Neighboring gene predicted gene, 34483

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in D-aspartate import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in D-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-aspartate import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-glutamate import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-glutamate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-glutamate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamate import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within L-glutamate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within L-glutamate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cysteine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within monoatomic anion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter reuptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter reuptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotrimerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to amino acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within telencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within visual behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in astrocyte projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of membrane protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    excitatory amino acid transporter 2
    Names
    EAAT2 variant mEAAT2/5UT2
    EAAT2 variant mEAAT2/5UT5
    glutamate transporter 1c
    sodium-dependent glutamate/aspartate transporter 2
    solute carrier family 1, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077514.4NP_001070982.1  excitatory amino acid transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_001070982.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK134609, AL844155
      Consensus CDS
      CCDS38188.1
      UniProtKB/Swiss-Prot
      O35877, O54686, O54687, P43006
      UniProtKB/TrEMBL
      Q3USU5, Q3UYK6
      Related
      ENSMUSP00000079100.4, ENSMUST00000080210.10
      Conserved Domains (1) summary
      pfam00375
      Location:46495
      SDF; Sodium:dicarboxylate symporter family
    2. NM_001077515.2NP_001070983.1  excitatory amino acid transporter 2 isoform 2

      See identical proteins and their annotated locations for NP_001070983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK134609, AL844155, AL844605
      Consensus CDS
      CCDS38189.1
      UniProtKB/TrEMBL
      A2APL8, Q3USU5
      Related
      ENSMUSP00000106843.2, ENSMUST00000111212.8
      Conserved Domains (1) summary
      pfam00375
      Location:43492
      SDF; Sodium:dicarboxylate symporter family
    3. NM_001361018.1NP_001347947.1  excitatory amino acid transporter 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844155, AL844605
      Consensus CDS
      CCDS89527.1
      UniProtKB/TrEMBL
      A2APL5, X2D841
      Related
      ENSMUSP00000106844.2, ENSMUST00000111213.8
      Conserved Domains (1) summary
      pfam00375
      Location:46495
      SDF; Sodium:dicarboxylate symporter family
    4. NM_011393.2NP_035523.1  excitatory amino acid transporter 2 isoform 3

      See identical proteins and their annotated locations for NP_035523.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL844155, AL844605
      Consensus CDS
      CCDS16469.1
      UniProtKB/TrEMBL
      A2APL7, X2D841
      Related
      ENSMUSP00000005220.5, ENSMUST00000005220.11
      Conserved Domains (1) summary
      pfam00375
      Location:43492
      SDF; Sodium:dicarboxylate symporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      102488584..102621129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248894.1XP_030104754.1  excitatory amino acid transporter 2 isoform X1

      UniProtKB/TrEMBL
      Q3USU5
      Conserved Domains (1) summary
      pfam00375
      Location:37486
      SDF; Sodium:dicarboxylate symporter family
    2. XM_006499047.4XP_006499110.1  excitatory amino acid transporter 2 isoform X2

      UniProtKB/TrEMBL
      X2D841
      Conserved Domains (1) summary
      pfam00375
      Location:46495
      SDF; Sodium:dicarboxylate symporter family
    3. XM_011239398.4XP_011237700.1  excitatory amino acid transporter 2 isoform X1

      UniProtKB/TrEMBL
      Q3USU5
      Conserved Domains (1) summary
      pfam00375
      Location:37486
      SDF; Sodium:dicarboxylate symporter family
    4. XM_030248893.1XP_030104753.1  excitatory amino acid transporter 2 isoform X1

      UniProtKB/TrEMBL
      Q3USU5
      Conserved Domains (1) summary
      pfam00375
      Location:37486
      SDF; Sodium:dicarboxylate symporter family