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    Ncbp2 nuclear cap binding protein subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 68092, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ncbp2provided by MGI
    Official Full Name
    nuclear cap binding protein subunit 2provided by MGI
    Primary source
    MGI:MGI:1915342
    See related
    Ensembl:ENSMUSG00000022774 AllianceGenome:MGI:1915342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    20kDa; 5930413E18Rik
    Summary
    Predicted to enable nucleic acid binding activity. Involved in histone mRNA metabolic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of nuclear cap binding activity complex. Is expressed in genitourinary system. Orthologous to several human genes including NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 49.7), CNS E14 (RPKM 29.8) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Ncbp2 in Genome Data Viewer
    Location:
    16 B2; 16 22.4 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31767364..31777290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31948546..31958472)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Z Neighboring gene Ncbp2 antisense 2 (head to head) Neighboring gene SUMO/sentrin specific peptidase 5 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA 7-methylguanosine cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in alternative mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cap-dependent translational initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in histone mRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA 3'-end processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mRNA cis splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of RNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in primary miRNA processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in snRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in snRNA export from nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear cap binding complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nuclear cap-binding protein subunit 2
    Names
    20 kDa nuclear cap-binding protein
    CBP20
    NCBP 20 kDa subunit
    nuclear cap binding protein subunit 2, 20kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026554.4NP_080830.1  nuclear cap-binding protein subunit 2

      See identical proteins and their annotated locations for NP_080830.1

      Status: VALIDATED

      Source sequence(s)
      AI843301, AK077841, AK147027, BY035864
      Consensus CDS
      CCDS28110.1
      UniProtKB/Swiss-Prot
      Q0VF93, Q3UI86, Q9CQ49
      UniProtKB/TrEMBL
      A0A1S6GWH9
      Related
      ENSMUSP00000023460.7, ENSMUST00000023460.7
      Conserved Domains (1) summary
      cd12240
      Location:42119
      RRM_NCBP2; RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31767364..31777290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)