Tmem65 transmembrane protein 65 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem65provided by MGI
Official Full Name: transmembrane protein 65provided by MGI
Primary source: MGI:MGI:1922118
See related: Ensembl:ENSMUSG00000062373 AllianceGenome:MGI:1922118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610029O13Rik; 4930438D12Rik
Summary: Involved in cardiac conduction; cardiac ventricle development; and regulation of cardiac conduction. Located in intercalated disc and plasma membrane. Is expressed in dentate gyrus subgranular zone. Orthologous to human TMEM65 (transmembrane protein 65). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 30.6), cerebellum adult (RPKM 15.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 25.09 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (58654118..58695510, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (58782269..58823663, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Title: Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Tmem65 is an intercalated disc protein that interacts with and functionally regulates ventricular Cx43.
Title: Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac ventricle development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175212.4 → NP_780421.2 transmembrane protein 65

See identical proteins and their annotated locations for NP_780421.2

Status: PROVISIONAL

Source sequence(s)

AC107772

Consensus CDS

CCDS27493.1

UniProtKB/Swiss-Prot

Q4VAE3, Q810S8

Related

ENSMUSP00000071984.6, ENSMUST00000072113.6

Conserved Domains (1) summary

pfam10507
Location:114 → 221

DUF2453; Protein of unknown function (DUF2453)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

58654118..58695510 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521504.5 → XP_006521567.1 transmembrane protein 65 isoform X1

Conserved Domains (1) summary

pfam10507
Location:141 → 248

TMEM65; Transmembrane protein 65
XM_036159621.1 → XP_036015514.1 transmembrane protein 65 isoform X2

Conserved Domains (1) summary

pfam10507
Location:36 → 143

TMEM65; Transmembrane protein 65
XM_011245759.4 → XP_011244061.1 transmembrane protein 65 isoform X3