Strn striatin, calmodulin binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Strnprovided by MGI
Official Full Name: striatin, calmodulin binding proteinprovided by MGI
Primary source: MGI:MGI:1333757
See related: Ensembl:ENSMUSG00000024077 AllianceGenome:MGI:1333757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D130055P19
Summary: Predicted to enable several functions, including armadillo repeat domain binding activity; calmodulin binding activity; and nuclear estrogen receptor binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; dendrite development; and locomotory behavior. Predicted to be located in several cellular components, including bicellular tight junction; dendritic spine; and postsynaptic membrane. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in dendrite. Is expressed in central nervous system and retina. Orthologous to human STRN (striatin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 6.6), cortex adult (RPKM 6.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 49.54 cM; 17 E3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (78957327..79043990, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (78649898..78737322, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

striatin deficiency is associated with salt sensitivity of blood pressure, enhanced vasoconstriction, and decreased vascular relaxation, suggesting a critical role for striatin in regulation of vascular function and BP during changes in sodium intake.
Title: Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake.
the rapid, nongenomic mineralocorticoid receptor pathway (mediated via striatin) has a role in modulating the interaction between salt intake and blood pressure.
Title: Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans.
these results provide evidence that increased striatin levels is a component of MR activation in the vasculature and suggest that regulation of striatin by ALDO may modulate estrogen's nongenomic effects.
Title: Activation of the mineralocorticoid receptor increases striatin levels.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237699

NoName (e-PCR)
- UniSTS:237700

NoName (e-PCR)
- UniSTS:237702

NoName (e-PCR)
- UniSTS:237706

RH126282 (e-PCR)
- UniSTS:162990

AU022939 (e-PCR)
- UniSTS:160696

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IEA Inferred from Electronic Annotation more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	IEA Inferred from Electronic Annotation more info
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: striatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413756.1 → NP_001400685.1 striatin isoform 2

Status: VALIDATED

Source sequence(s)

AC151284
NM_011500.3 → NP_035630.2 striatin isoform 1

See identical proteins and their annotated locations for NP_035630.2

Status: VALIDATED

Source sequence(s)

AC151284, BC090968

Consensus CDS

CCDS28978.1

UniProtKB/Swiss-Prot

B2RWV9, O55106, Q5BKR9

UniProtKB/TrEMBL

Q3UWX9

Related

ENSMUSP00000120830.3, ENSMUST00000145910.9

Conserved Domains (4) summary

COG2319
Location:449 → 778

WD40; WD40 repeat [General function prediction only]

cd00200
Location:455 → 779

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:48 → 173

Striatin; Striatin family

sd00039
Location:468 → 514

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

78957327..79043990 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160632.1 → XP_036016525.1 striatin isoform X2

UniProtKB/TrEMBL

F8WH41

Related

ENSMUSP00000024881.8, ENSMUST00000024881.14

Conserved Domains (2) summary

cd00200
Location:267 → 591

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:280 → 326

7WD40; WD40 repeat [structural motif]