Rnft1 ring finger protein, transmembrane 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnft1provided by MGI
Official Full Name: ring finger protein, transmembrane 1provided by MGI
Primary source: MGI:MGI:1924142
See related: Ensembl:ENSMUSG00000020521 AllianceGenome:MGI:1924142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610013E23Rik
Summary: Predicted to enable ubiquitin binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway and protein autoubiquitination. Predicted to be located in early endosome membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human RNFT1 (ring finger protein, transmembrane 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 6.6), limb E14.5 (RPKM 4.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.82 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (86375483..86389833)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (86484657..86499007)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AV007605 (e-PCR)
- UniSTS:164473

AA959758 (e-PCR)
- UniSTS:160138

RH139016 (e-PCR)
- UniSTS:221102

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNFT1

Names: RING finger and transmembrane domain-containing protein 1

NP_084064.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029788.5 → NP_084064.1 E3 ubiquitin-protein ligase RNFT1

See identical proteins and their annotated locations for NP_084064.1

Status: PROVISIONAL

Source sequence(s)

AL604063

Consensus CDS

CCDS25200.1

UniProtKB/Swiss-Prot

Q3U649, Q80X62, Q9DCN7

Related

ENSMUSP00000020827.7, ENSMUST00000020827.7

Conserved Domains (1) summary

cd00162
Location:335 → 376

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...