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    Cope coatomer protein complex, subunit epsilon [ Mus musculus (house mouse) ]

    Gene ID: 59042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Copeprovided by MGI
    Official Full Name
    coatomer protein complex, subunit epsilonprovided by MGI
    Primary source
    MGI:MGI:1891702
    See related
    Ensembl:ENSMUSG00000055681 AllianceGenome:MGI:1891702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cope1; 1110005D17Rik
    Summary
    Predicted to enable structural molecule activity. Acts upstream of or within protein localization to axon. Located in COPI-coated vesicle. Is expressed in cerebral cortex. Orthologous to human COPE (COPI coat complex subunit epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 240.8), ovary adult (RPKM 233.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cope in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70755417..70765652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70302767..70313002)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38427 Neighboring gene homer scaffolding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8240 Neighboring gene DEAD box helicase 49 Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 RNA helicase and ATPase Neighboring gene STARR-seq mESC enhancer starr_21770 Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of human 19p12-13 region in Fugu and mouse. Clarke D, et al. Mamm Genome, 2001 Jun. PMID 11353399
    2. The COPI vesicle complex binds and moves with survival motor neuron within axons. Peter CJ, et al. Hum Mol Genet, 2011 May 1. PMID 21300694, Free PMC Article
    3. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249
    4. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471
    5. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit epsilon
    Names
    epsilon-COP
    epsilon-coat protein
    nonclathrin coat protein epsilon-COP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021538.2 → NP_067513.1  coatomer subunit epsilon

      See identical proteins and their annotated locations for NP_067513.1

      Status: VALIDATED

      Source sequence(s)
      AC158553
      Consensus CDS
      CCDS22365.1
      UniProtKB/Swiss-Prot
      O89079, Q9JM65
      UniProtKB/TrEMBL
      Q9D1J2
      Related
      ENSMUSP00000071078.8, ENSMUST00000066469.14
      Conserved Domains (2) summary
      sd00006
      Location:185 → 210
      TPR; TPR repeat [structural motif]
      pfam04733
      Location:17 → 305
      Coatomer_E; Coatomer epsilon subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70755417..70765652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89079.3 GenPept UniProtKB/Swiss-Prot:O89079

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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