Apip APAF1 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apipprovided by MGI
Official Full Name: APAF1 interacting proteinprovided by MGI
Primary source: MGI:MGI:1926788
See related: Ensembl:ENSMUSG00000010911 AllianceGenome:MGI:1926788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: APIP2; CGI-29; Mmrp19
Summary: Predicted to enable identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Involved in negative regulation of apoptotic process and regulation of ERK1 and ERK2 cascade. Predicted to be active in cytoplasm. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 17.9), limb E14.5 (RPKM 12.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.29 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (102904020..102922994)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (103073675..103092649)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

APIP is crucial for cardioprotection against myocardial infarction by virtue of binding to and stabilizing ADORA2B, thereby dampening ischemic heart injury.
Title: Cardioprotective role of APIP in myocardial infarction through ADORA2B.
APIP functions to inhibit muscle ischemic damage by binding to Apaf-1 in the Apaf-1/caspase-9 apoptosis pathway.
Title: Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit388 (e-PCR), detects polymorphism
- UniSTS:129287

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methylthioribulose 1-phosphate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylthioribulose 1-phosphate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables methylthioribulose 1-phosphate dehydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage from methylthioadenosine	ISO Inferred from Sequence Orthology more info
involved_in L-methionine salvage from methylthioadenosine	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: methylthioribulose-1-phosphate dehydratase

Names: MTRu-1-P dehydratase; monocyte macrophage 19; monocyte/macrophage protein 19; probable methylthioribulose-1-phosphate dehydratase

NP_001342402.1

EC 4.2.1.109

NP_001342403.1

EC 4.2.1.109

NP_062709.3

EC 4.2.1.109

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355473.1 → NP_001342402.1 methylthioribulose-1-phosphate dehydratase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL954375

Conserved Domains (1) summary

TIGR03328
Location:27 → 212

salvage_mtnB; methylthioribulose-1-phosphate dehydratase
NM_001355474.1 → NP_001342403.1 methylthioribulose-1-phosphate dehydratase isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL954375

Related

ENSMUST00000124540.8

Conserved Domains (1) summary

cl00214
Location:1 → 154

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_019735.4 → NP_062709.3 methylthioribulose-1-phosphate dehydratase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK077705, AK145450, AV060627

Consensus CDS

CCDS16474.1

UniProtKB/Swiss-Prot

Q8BP46, Q9WVQ5

Related

ENSMUSP00000011055.7, ENSMUST00000011055.7

Conserved Domains (1) summary

TIGR03328
Location:27 → 225

salvage_mtnB; methylthioribulose-1-phosphate dehydratase