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    Srsf3 serine and arginine-rich splicing factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 20383, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Srsf3provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 3provided by MGI
    Primary source
    MGI:MGI:98285
    See related
    Ensembl:ENSMUSG00000071172 AllianceGenome:MGI:98285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    X16; Sfrs3
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
    Expression
    Broad expression in CNS E11.5 (RPKM 128.5), CNS E14 (RPKM 91.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srsf3 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.03 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29251634..29262346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29032660..29043372)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 Neighboring gene predicted gene, 23887 Neighboring gene STARR-seq mESC enhancer starr_42244 Neighboring gene STARR-seq mESC enhancer starr_42246 Neighboring gene predicted gene 16196 Neighboring gene STARR-seq mESC enhancer starr_42249 Neighboring gene STARR-seq mESC enhancer starr_42251 Neighboring gene tumor protein p53 pathway corepressor 1 Neighboring gene predicted gene, 41556 Neighboring gene STARR-seq mESC enhancer starr_42255 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29218945-29219128 Neighboring gene STARR-seq mESC enhancer starr_42257 Neighboring gene STARR-seq mESC enhancer starr_42258 Neighboring gene cyclin dependent kinase inhibitor 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role. Dumont AA, et al. FASEB J, 2021 May. PMID 33819356
    2. Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts. Boutej H, et al. Cell Rep, 2017 Dec 12. PMID 29241548
    3. Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates. Ajiro M, et al. Int J Biol Sci, 2015. PMID 26435690, Free PMC Article
    4. Degradation of splicing factor SRSF3 contributes to progressive liver disease. Kumar D, et al. J Clin Invest, 2019 Aug 8. PMID 31393851, Free PMC Article
    5. The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production. Heazlewood SY, et al. Blood, 2022 Mar 3. PMID 34852174, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
      Title: Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
    2. Serine and Arginine-Rich Splicing Factor 3 Promotes the Activation of Quiescent Mouse Neural Stem Cells.
      Title: Serine and Arginine-Rich Splicing Factor 3 Promotes the Activation of Quiescent Mouse Neural Stem Cells.
    3. LincRNA-EPS Alleviates Inflammation in TMJ Osteoarthritis by Binding to SRSF3.
      Title: LincRNA-EPS Alleviates Inflammation in TMJ Osteoarthritis by Binding to SRSF3.
    4. Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma.
      Title: Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma.
    5. hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
      Title: hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
    6. The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production.
      Title: The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production.
    7. SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
      Title: SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
    8. Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors.
      Title: Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors.
    9. Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha signaling in the facial mesenchyme.
      Title: Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.
    10. Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role.
      Title: Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables primary miRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-RNA sequence-specific adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-RNA sequence-specific adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in primary miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 3
    Names
    pre-mRNA-splicing factor SRP20
    splicing factor, arginine/serine-rich 3 (SRp20)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013663.6 → NP_038691.1  serine/arginine-rich splicing factor 3

      See identical proteins and their annotated locations for NP_038691.1

      Status: REVIEWED

      Source sequence(s)
      AC167363
      Consensus CDS
      CCDS28590.1
      UniProtKB/Swiss-Prot
      P84104, Q564E9
      Related
      ENSMUSP00000117045.2, ENSMUST00000130216.3
      Conserved Domains (1) summary
      cd12645
      Location:6 → 86
      RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)

    RNA

    1. NR_036613.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC167363
      Related
      ENSMUST00000037776.16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29251634..29262346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84104.1 GenPept UniProtKB/Swiss-Prot:P84104

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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