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    Rsrc2 arginine/serine-rich coiled-coil 2 [ Mus musculus (house mouse) ]

    Gene ID: 208606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rsrc2provided by MGI
    Official Full Name
    arginine/serine-rich coiled-coil 2provided by MGI
    Primary source
    MGI:MGI:1913489
    See related
    Ensembl:ENSMUSG00000029422 AllianceGenome:MGI:1913489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500011J06Rik
    Summary
    Is expressed in embryo. Orthologous to human RSRC2 (arginine and serine rich coiled-coil 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 41.6), CNS E14 (RPKM 26.5) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rsrc2 in Genome Data Viewer
    Location:
    5 F; 5 63.15 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123866489..123887522, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123728426..123749429, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, CCHC domain containing 8 Neighboring gene STARR-seq mESC enhancer starr_14326 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E104 Neighboring gene kinetochore associated 1 Neighboring gene hydroxycarboxylic acid receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
    2. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    3. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    arginine/serine-rich coiled-coil protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005525.2 → NP_001005525.1  arginine/serine-rich coiled-coil protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC129582, AW557796, BC132550, BP772863
      Consensus CDS
      CCDS39271.1
      UniProtKB/TrEMBL
      S4R2L4
      Related
      ENSMUSP00000138691.2, ENSMUST00000182309.8
      Conserved Domains (1) summary
      pfam15477
      Location:354 → 423
      SMAP; Small acidic protein family

    2. NM_001359860.1 → NP_001346789.1  arginine/serine-rich coiled-coil protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 2 and 4, encodes isoform 2.
      Source sequence(s)
      AC129582
      Consensus CDS
      CCDS39272.1
      UniProtKB/Swiss-Prot
      A2RTL5
      Conserved Domains (1) summary
      pfam15477
      Location:296 → 365
      SMAP; Small acidic protein family

    3. NM_001359861.1 → NP_001346790.1  arginine/serine-rich coiled-coil protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform 2.
      Source sequence(s)
      AC129582
      Consensus CDS
      CCDS39272.1
      UniProtKB/Swiss-Prot
      A2RTL5
      Related
      ENSMUSP00000050563.8, ENSMUST00000050827.14
      Conserved Domains (1) summary
      pfam15477
      Location:296 → 365
      SMAP; Small acidic protein family

    4. NM_001359864.1 → NP_001346793.1  arginine/serine-rich coiled-coil protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC129582
      Conserved Domains (1) summary
      pfam15477
      Location:353 → 422
      SMAP; Small acidic protein family

    5. NM_001359865.1 → NP_001346794.1  arginine/serine-rich coiled-coil protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform 4.
      Source sequence(s)
      AC129582
      UniProtKB/TrEMBL
      B7ZNU2
      Conserved Domains (1) summary
      pfam15477
      Location:295 → 364
      SMAP; Small acidic protein family

    6. NM_001359866.1 → NP_001346795.1  arginine/serine-rich coiled-coil protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform 4.
      Source sequence(s)
      AC129582
      UniProtKB/TrEMBL
      B7ZNU2
      Conserved Domains (1) summary
      pfam15477
      Location:295 → 364
      SMAP; Small acidic protein family

    7. NM_025438.2 → NP_079714.1  arginine/serine-rich coiled-coil protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1. Variants 2, 3, and 4 all encode the same isoform (2).
      Source sequence(s)
      AC129582, BP772863
      Consensus CDS
      CCDS39272.1
      UniProtKB/Swiss-Prot
      A2RTL5
      Related
      ENSMUSP00000049942.6, ENSMUST00000057795.12
      Conserved Domains (1) summary
      pfam15477
      Location:296 → 365
      SMAP; Small acidic protein family

    RNA

    1. NR_153355.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    2. NR_153356.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    3. NR_153357.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    4. NR_153358.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    5. NR_153359.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    6. NR_153360.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    7. NR_153361.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    8. NR_153362.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129582

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123866489..123887522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530244.5 → XP_006530307.1  arginine/serine-rich coiled-coil protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15477
      Location:306 → 375
      SMAP; Small acidic protein family

    2. XM_006530241.5 → XP_006530304.1  arginine/serine-rich coiled-coil protein 2 isoform X1

      UniProtKB/TrEMBL
      S4R265
      Conserved Domains (1) summary
      pfam15477
      Location:307 → 376
      SMAP; Small acidic protein family

    3. XM_011248190.4 → XP_011246492.1  arginine/serine-rich coiled-coil protein 2 isoform X3

      UniProtKB/TrEMBL
      B7ZNU2
      Conserved Domains (1) summary
      pfam15477
      Location:295 → 364
      SMAP; Small acidic protein family

    4. XM_006530242.5 → XP_006530305.1  arginine/serine-rich coiled-coil protein 2 isoform X1

      UniProtKB/TrEMBL
      S4R265
      Related
      ENSMUSP00000138518.2, ENSMUST00000182489.8
      Conserved Domains (1) summary
      pfam15477
      Location:307 → 376
      SMAP; Small acidic protein family

    5. XM_006530243.5 → XP_006530306.1  arginine/serine-rich coiled-coil protein 2 isoform X1

      UniProtKB/TrEMBL
      S4R265
      Conserved Domains (1) summary
      pfam15477
      Location:307 → 376
      SMAP; Small acidic protein family

    RNA

    1. XR_004942474.1 RNA Sequence

    2. XR_001784647.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005523.1: Suppressed sequence

      Description
      NM_001005523.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RTL5.1 GenPept UniProtKB/Swiss-Prot:A2RTL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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