Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts4provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 4provided by MGI
Primary source: MGI:MGI:1339949
See related: Ensembl:ENSMUSG00000006403 AllianceGenome:MGI:1339949
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADMP-1; ADAM-TS4; ADAMTS-2
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016]
Expression: Broad expression in ovary adult (RPKM 13.3), cerebellum adult (RPKM 7.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.28 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171077698..171089836)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171250129..171262267)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition.
Title: ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition.
Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner.
Title: Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner.
ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRalpha Signaling.
Title: ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRα Signaling.
ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711.
Title: ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711.
Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
Title: Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.
Title: MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.
Exuberant fibroblast activity compromises lung function via ADAMTS4.
Title: Exuberant fibroblast activity compromises lung function via ADAMTS4.
ADAMTS4 was exclusively expressed in oligodendrocytes
Title: The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Aortas in Adamts-4-/- mice showed reduced elastic fiber destruction, versican degradation, macrophage infiltration, and apoptosis. Interestingly, Adamts-4 was directly involved in smooth muscle cell (SMC) apoptosis. Study findings indicate that Adamts-4 induces SMC apoptosis, degrades versican, promotes inflammatory cell infiltration, and thus contributes to sporadic aortic aneurysm and dissection development.
Title: Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth.
Title: Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (10) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234266

NoName (e-PCR)
- UniSTS:548431

Adamts4 (e-PCR), detects polymorphism
- UniSTS:495974

D1S3690 (e-PCR)
- UniSTS:474268

Adamts4 (e-PCR), detects polymorphism
- UniSTS:532651

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 4

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; aggrecanase-1

NP_766433.2

EC 3.4.24.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172845.3 → NP_766433.2 A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein

Status: REVIEWED

Source sequence(s)

AC084821, AC087229, AK083534

Consensus CDS

CCDS15485.2

UniProtKB/Swiss-Prot

Q8BNJ2, Q8K384

UniProtKB/TrEMBL

Q3TNX8

Related

ENSMUSP00000106947.4, ENSMUST00000111315.9

Conserved Domains (6) summary

smart00209
Location:527 → 571

TSP1; Thrombospondin type 1 repeats

cd04273
Location:214 → 421

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:214 → 424

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:74 → 177

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:683 → 798

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:434 → 505

ADAM_CR; ADAM cysteine-rich