Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sgtaprovided by RGD
Official Full Name: small glutamine rich tetratricopeptide repeat co-chaperone alphaprovided by RGD
Primary source: RGD:620815
See related: EnsemblRapid:ENSRNOG00000019891 AllianceGenome:RGD:620815
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stg
Summary: Enables identical protein binding activity. Involved in chaperone-mediated protein folding; protein heterooligomerization; and protein homooligomerization. Is active in presynapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 210.8), Muscle (RPKM 173.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9304381..9321157)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8653681..8670460)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11521949..11538691)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SGTA is involved in biochemical and physiological responses after spinal cord injury.
Title: Expression of SGTA correlates with neuronal apoptosis and reactive gliosis after spinal cord injury.
brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein
Title: A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BAT3 complex binding	IEA Inferred from Electronic Annotation more info
enables BAT3 complex binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein folding	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TRC complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of synaptic vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small glutamine-rich tetratricopeptide repeat-containing protein alpha

Names: alpha-SGT; small glutamine rich tetratricopeptide repeat containing alpha; small glutamine-rich protein with tetratricopeptide repeats 1; small glutamine-rich tetratricopeptide repeat (TPR) containing protein (SGT); small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022703.3 → NP_073194.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha

See identical proteins and their annotated locations for NP_073194.1

Status: PROVISIONAL

Source sequence(s)

BC087642

UniProtKB/Swiss-Prot

O70593, Q548F5

UniProtKB/TrEMBL

A0A8L2QED2, A6K8D2

Related

ENSRNOP00000081994.2, ENSRNOT00000105493.2

Conserved Domains (3) summary

PLN03088
Location:105 → 211

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:91 → 119

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerization domain of SGTA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9304381..9321157

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240996.4 → XP_006241058.3 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

UniProtKB/TrEMBL

A0A8L2QED2

Related

ENSRNOP00000086443.2, ENSRNOT00000115492.2

Conserved Domains (3) summary

PLN03088
Location:160 → 266

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:146 → 174

TPR; TPR repeat [structural motif]

pfam16546
Location:59 → 118

SGTA_dimer; Homodimerization domain of SGTA