Chrnb3 cholinergic receptor nicotinic beta 3 subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chrnb3provided by RGD
Official Full Name: cholinergic receptor nicotinic beta 3 subunitprovided by RGD
Primary source: RGD:621544
See related: EnsemblRapid:ENSRNOG00000012448 AllianceGenome:RGD:621544
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables acetylcholine binding activity. Contributes to heterocyclic compound binding activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Part of acetylcholine-gated channel complex. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 11.5), Brain (RPKM 4.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (71411847..71454225, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (64713438..64751360, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (68876442..68913628, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the affinity of alpha-CTxLvIA selectively blocks alpha3beta2 vs. alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors.
Title: A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.
Positional scanning mutagenesis of alpha-conotoxin PeIA identifies critical residues that confer potency and selectivity for alpha6/alpha3beta2beta3 and alpha3beta2 nicotinic acetylcholine receptors
Title: Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.
The concentration of beta3- and alpha6- containing neuronal nicotinic acetylcholine receptors (nAChRs) is higher in the optic nerve than in any other area of the rat brain.
Title: Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC18423P1 (e-PCR)
- UniSTS:271686

Chrnb3 (e-PCR), detects polymorphism
- UniSTS:256427

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholine binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IC Inferred by Curator more info	PubMed
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
contributes_to heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in response to nicotine	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of acetylcholine-gated channel complex	TAS Traceable Author Statement more info	PubMed
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit beta-3

Names: cholinergic receptor, nicotinic beta 3; cholinergic receptor, nicotinic, beta 3 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133597.2 → NP_598281.1 neuronal acetylcholine receptor subunit beta-3 precursor

See identical proteins and their annotated locations for NP_598281.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P12391

UniProtKB/TrEMBL

A6IVW9, Q6PW48

Related

ENSRNOP00000016656.3, ENSRNOT00000016656.6

Conserved Domains (3) summary

TIGR00860
Location:29 → 455

LIC; Cation transporter family protein

pfam02931
Location:35 → 239

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:246 → 452

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

71411847..71454225 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094179.2 → XP_038950107.1 neuronal acetylcholine receptor subunit beta-3 isoform X1

UniProtKB/TrEMBL

Q6PW48

Conserved Domains (1) summary

TIGR00860
Location:1 → 375

LIC; Cation transporter family protein
XM_039094178.2 → XP_038950106.1 neuronal acetylcholine receptor subunit beta-3 isoform X2

Conserved Domains (1) summary

TIGR00860
Location:1 → 320

LIC; Cation transporter family protein