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    P2ry4 pyrimidinergic receptor P2Y4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P2ry4provided by RGD
    Official Full Name
    pyrimidinergic receptor P2Y4provided by RGD
    Primary source
    RGD:61798
    See related
    EnsemblRapid:ENSRNOG00000070777 AllianceGenome:RGD:61798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P2Y4
    Summary
    Enables ATP binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 16.9), Lung (RPKM 14.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See P2ry4 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (69722604..69757726, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (65681680..65717404, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (70421599..70447109, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol O-acyltransferase 2-like 6 Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene arrestin 3 Neighboring gene uncharacterized LOC120099344 Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways. Szrejder M, et al. Arch Biochem Biophys, 2020 Nov 30. PMID 33122160
    2. Molecular cloning and characterization of the rat P2Y4 receptor. Webb TE, et al. J Neurochem, 1998 Oct. PMID 9751165
    3. Changes in P2Y4 receptor expression in rat cochlear outer sulcus cells during development. Lee JH, et al. Hear Res, 2007 Jun. PMID 17433586
    4. Localization and possible function of P2Y(4) receptors in the rodent retina. Ward MM, et al. Neuroscience, 2008 Sep 9. PMID 18625291
    5. IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE. Dosh RH, et al. Wiad Lek, 2022. PMID 36591760

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE.
      Title: IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE.
    2. Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways.
      Title: Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways.
    3. Activation of renal medullary P2Y2/P2Y4 receptors promotes ET-1-dependent natriuresis in ovariectomized rats.
      Title: Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.
    4. in 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by R2Y2 receptors. R2Y4 receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups
      Title: Involvement of P2Y(2,4) receptors in the regulation of myocardial contractility in growing rats.
    5. Amyloid precursor protein (APP) production and secretion is regulated by activation of P2Y2/4 receptors coupled to protein kinase signaling pathways, in a demonstration using astrocytes as a potential source of APP.
      Title: P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes.
    6. P2Y2 and P2Y4 receptors in granulosa cells modulate Cl- permeability by regulating Ca2+-release.
      Title: Purinergic signalling in rat GFSHR-17 granulosa cells: an in vitro model of granulosa cells in maturing follicles.
    7. P(2y2) and/or P(2y4) receptors may be involved in the enhanced purinergic signaling in lithium induced nephrogenic diabetes insipidus
      Title: Potential role of purinergic signaling in lithium-induced nephrogenic diabetes insipidus.
    8. expression of P2Y(4) receptors on rod bipolar cell axon terminals is reduced following dark adaptation, suggesting receptor expression may be dependent on retinal activity.
      Title: Localization and possible function of P2Y(4) receptors in the rodent retina.
    9. Cultured rat urothelial cells functionally express P2Y(2)/P2Y(4) receptors.
      Title: Expression and function of rat urothelial P2Y receptors.
    10. ATP analogs biphasically modulate the evoked release of glutamate from purified nerve terminals of the rat hippocampus, the inhibition being mediated by P2Y1, P2Y2, and/or P2Y4
      Title: Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled UTP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled UTP receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to prostaglandin E stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within transepithelial chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P2Y purinoceptor 4
    Names
    P2Y ATP receptor 4
    purinergic receptor P2Y, G-protein coupled 4
    pyrimidinergic receptor P2Y, G-protein coupled, 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031680.1 → NP_113868.1  P2Y purinoceptor 4

      See identical proteins and their annotated locations for NP_113868.1

      Status: PROVISIONAL

      Source sequence(s)
      Y11433
      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000100377.1, ENSRNOT00000133132.1
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      69722604..69757726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100015.2 → XP_038955943.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000111152.1, ENSRNOT00000125396.1
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_039100012.2 → XP_038955940.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_063280275.1 → XP_063136345.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78

    4. XM_039100009.2 → XP_038955937.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_039100014.2 → XP_038955942.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_039100011.2 → XP_038955939.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. XM_063280274.1 → XP_063136344.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000111265.1, ENSRNOT00000167412.1

    8. XM_039100007.2 → XP_038955935.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    9. XM_063280276.1 → XP_063136346.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000082634.1, ENSRNOT00000112073.2

    10. XM_039100006.2 → XP_038955934.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000104440.1, ENSRNOT00000121214.1
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    11. XM_063280273.1 → XP_063136343.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000102816.1, ENSRNOT00000147730.1

    12. XM_039100005.2 → XP_038955933.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000111264.1, ENSRNOT00000134670.1
      Conserved Domains (1) summary
      cd15374
      Location:32 → 313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35811.1 GenPept UniProtKB/Swiss-Prot:O35811

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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