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    Igfbp6 insulin-like growth factor binding protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igfbp6provided by RGD
    Official Full Name
    insulin-like growth factor binding protein 6provided by RGD
    Primary source
    RGD:2877
    See related
    EnsemblRapid:ENSRNOG00000010977 AllianceGenome:RGD:2877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RBP6A; RBP6G; IGF-BP6
    Summary
    Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and regulation of insulin-like growth factor receptor signaling pathway. Located in extracellular space. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 1152.5), Muscle (RPKM 657.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igfbp6 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135154919..135159550)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133276309..133280944)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143749385..143754018)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479789 Neighboring gene tensin 2 Neighboring gene SPRY domain containing 3 Neighboring gene sterol O-acyltransferase 2 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zinc finger protein 740

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis. Wang S, et al. Neurochem Res, 2017 Feb. PMID 27888466
    2. Structural characterization of the rat insulin-like growth factor binding protein-6 gene. Zhu X, et al. Biochem Biophys Res Commun, 1993 Mar 31. PMID 7682065
    3. Rat PC12 pheochromocytoma cells synthesize insulin-like growth factor-binding protein-6. Bach LA, et al. Endocrinology, 1993 Sep. PMID 7689963
    4. Structure-function relationships of insulin-like growth factor binding protein 6 (IGFBP-6) and its chimeras. Boes M, et al. Growth Horm IGF Res, 2002 Apr. PMID 12175646
    5. Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells. Kühl NM, et al. Glia, 2003 Nov. PMID 14515325

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IGFBP-6 was significantly up-regulated adjacent to the hematoma following intracerebral hemorrhage.
      Title: Insulin-like Growth Factor Binding Protein6 Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats.
    2. Following spinal cord injury, IGFBP6 was significantly up-regulated.
      Title: The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis.
    3. IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation.
      Title: Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.
    4. Toxic effect of TCDD on osteogenesis through altering Igfbp6 gene expression in osteoblasts is reported.
      Title: Toxic effects of TCDD on osteogenesis through altering IGFBP-6 gene expression in osteoblasts.
    5. IGFBP6 has a role in binding to endothelial cells and in transendothelial transportation
      Title: Structure-function relationships of insulin-like growth factor binding protein 6 (IGFBP-6) and its chimeras.
    6. IGFBP-6, a new negative effector of oligodendrocyte survival and differentiation, is expressed and localized to the Golgi complex in rat oligodendrocyte precursor (O2A) cells.
      Title: Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor I binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor II binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables insulin-like growth factor II binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin-like growth factor II binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of insulin-like growth factor binary complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 6
    Names
    IBP-6
    IGF-binding protein 6
    IGFBP-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013104.3 → NP_037236.1  insulin-like growth factor-binding protein 6 precursor

      See identical proteins and their annotated locations for NP_037236.1

      Status: PROVISIONAL

      Source sequence(s)
      M69055
      UniProtKB/Swiss-Prot
      P35572, Q499W1
      UniProtKB/TrEMBL
      A6KCS9
      Related
      ENSRNOP00000014807.4, ENSRNOT00000014807.8
      Conserved Domains (2) summary
      smart00121
      Location:28 → 97
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:148 → 220
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135154919..135159550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35572.1 GenPept UniProtKB/Swiss-Prot:P35572

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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