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    Pla2g4b phospholipase A2 group IVB [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pla2g4bprovided by RGD
    Official Full Name
    phospholipase A2 group IVBprovided by RGD
    Primary source
    RGD:1308658
    See related
    EnsemblRapid:ENSRNOG00000007447 AllianceGenome:RGD:1308658
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; calcium-dependent phospholipid binding activity; and phospholipase activity. Predicted to be involved in glycerophospholipid catabolic process; phosphatidylcholine acyl-chain remodeling; and phosphatidylethanolamine acyl-chain remodeling. Predicted to be located in early endosome membrane and mitochondrial inner membrane. Predicted to be active in cytosol. Orthologous to several human genes including PLA2G4B (phospholipase A2 group IVB). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 74.4), Heart (RPKM 65.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pla2g4b in Genome Data Viewer
    Location:
    3q35
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127458022..127467637)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107004238..107013853)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111824919..111833526)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein MGA Neighboring gene mitogen activated protein kinase binding protein 1 Neighboring gene jumonji domain containing 7 Neighboring gene spectrin, beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4 Neighboring gene phospholipase A2, group IVE

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of cytosolic phospholipase A2-beta. Song C, et al. J Biol Chem, 1999 Jun 11. PMID 10358058
    2. Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. Pickard RT, et al. J Biol Chem, 1999 Mar 26. PMID 10085124
    3. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. Ghosh M, et al. J Biol Chem, 2007 Apr 20. PMID 17293613, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic phospholipase A2 beta
    Names
    phospholipase A2, group IVB (cytosolic)
    NP_001101234.2
    XP_006234837.1
    XP_038960869.1
    XP_038960870.1
    XP_038960871.1
    XP_038960872.1
    XP_038960873.1
    XP_038960874.1
    XP_038960875.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107764.2 → NP_001101234.2  cytosolic phospholipase A2 beta

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4A1I6
      Related
      ENSRNOP00000061004.1, ENSRNOT00000066685.4
      Conserved Domains (3) summary
      cd04036
      Location:19 → 137
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam01735
      Location:304 → 728
      PLA2_B; Lysophospholipase catalytic domain
      cl11396
      Location:250 → 779
      Patatin_and_cPLA2; Patatins and Phospholipases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127458022..127467637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104942.1 → XP_038960870.1  cytosolic phospholipase A2 beta isoform X1

      Conserved Domains (3) summary
      cd04036
      Location:64 → 182
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:203 → 293
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:295 → 824
      Patatin_and_cPLA2; Patatins and Phospholipases

    2. XM_039104944.2 → XP_038960872.1  cytosolic phospholipase A2 beta isoform X2

      Conserved Domains (3) summary
      cd04036
      Location:10 → 128
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:149 → 239
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:241 → 770
      Patatin_and_cPLA2; Patatins and Phospholipases

    3. XM_039104943.2 → XP_038960871.1  cytosolic phospholipase A2 beta isoform X2

      Conserved Domains (3) summary
      cd04036
      Location:10 → 128
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:149 → 239
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:241 → 770
      Patatin_and_cPLA2; Patatins and Phospholipases

    4. XM_039104941.1 → XP_038960869.1  cytosolic phospholipase A2 beta isoform X1

      Conserved Domains (3) summary
      cd04036
      Location:64 → 182
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:203 → 293
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:295 → 824
      Patatin_and_cPLA2; Patatins and Phospholipases

    5. XM_006234775.4 → XP_006234837.1  cytosolic phospholipase A2 beta isoform X2

      See identical proteins and their annotated locations for XP_006234837.1

      UniProtKB/TrEMBL
      A0A0G2JZ44
      Conserved Domains (3) summary
      cd04036
      Location:10 → 128
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:149 → 239
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:241 → 770
      Patatin_and_cPLA2; Patatins and Phospholipases

    6. XM_039104945.1 → XP_038960873.1  cytosolic phospholipase A2 beta isoform X3

      Conserved Domains (2) summary
      pfam18695
      Location:31 → 121
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:123 → 652
      Patatin_and_cPLA2; Patatins and Phospholipases

    7. XM_039104947.2 → XP_038960875.1  cytosolic phospholipase A2 beta isoform X5

      Conserved Domains (1) summary
      cl11396
      Location:1 → 473
      Patatin_and_cPLA2; Patatins and Phospholipases

    8. XM_039104946.2 → XP_038960874.1  cytosolic phospholipase A2 beta isoform X4

      Conserved Domains (1) summary
      cl11396
      Location:2 → 482
      Patatin_and_cPLA2; Patatins and Phospholipases
    Nucleotide Protein Strain
    Heading Accession and Version

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