Eif4g1 eukaryotic translation initiation factor 4 gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif4g1provided by RGD
Official Full Name: eukaryotic translation initiation factor 4 gamma 1provided by RGD
Primary source: RGD:1306144
See related: EnsemblRapid:ENSRNOG00000001738 AllianceGenome:RGD:1306144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables eukaryotic initiation factor 4E binding activity. Involved in lung development and response to ethanol. Part of eukaryotic translation initiation factor 4F complex. Is active in postsynapse. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 862.7), Heart (RPKM 764.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (93726322..93746387, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (80221919..80241958, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (83907659..83927683, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrate that calpain-mediated degradation of a translation initiation factor, eIF4G1, is a cause of both persistent PSI and neuronal death
Title: Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death.
At birth increased Po(2) acts with glucocorticosteroid through an mTOR-related pathway to increase alpha-ENaC protein synthesis, thereby promoting lung fluid absorption.
Title: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
the eIF4E-eIF4G complex is more stringently required for plasticity induced by initial learning than for that triggered by reactivation of an existing memory.
Title: Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation.
eIF4E-eIF4G association and phosphorylation of 4E-BP1 and GSK-3 are increased after HFES in adult, but not in aged, animals.
Title: Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle.
IL-1 is the proinflammatory mediator responsible for the reduced level of phosphorylated eIF4G
Title: Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic initiation factor 4E binding	IPI Inferred from Physical Interaction more info	PubMed
enables eukaryotic initiation factor 4E binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables translation factor activity, RNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell periphery	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in translation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4 gamma 1

Names: eukaryotic translation initiation factor 4 gamma 1-like; voltage-dependent P/Q-type calcium channel subunit alpha-1A-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427476.1 → NP_001414405.1 eukaryotic translation initiation factor 4 gamma 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

D4AD15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

93726322..93746387 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270353.1 → XP_063126423.1 eukaryotic translation initiation factor 4 gamma 1 isoform X14

UniProtKB/TrEMBL

D4AD15
XM_063270352.1 → XP_063126422.1 eukaryotic translation initiation factor 4 gamma 1 isoform X13

UniProtKB/TrEMBL

D4AD15
XM_063270350.1 → XP_063126420.1 eukaryotic translation initiation factor 4 gamma 1 isoform X12

UniProtKB/TrEMBL

D4AD15
XM_063270348.1 → XP_063126418.1 eukaryotic translation initiation factor 4 gamma 1 isoform X11

UniProtKB/TrEMBL

D4AD15
XM_063270346.1 → XP_063126416.1 eukaryotic translation initiation factor 4 gamma 1 isoform X10

UniProtKB/TrEMBL

D4AD15
XM_063270343.1 → XP_063126413.1 eukaryotic translation initiation factor 4 gamma 1 isoform X8

UniProtKB/TrEMBL

D4AD15
XM_006248584.5 → XP_006248646.1 eukaryotic translation initiation factor 4 gamma 1 isoform X5

See identical proteins and their annotated locations for XP_006248646.1

UniProtKB/TrEMBL

D4AD15

Related

ENSRNOP00000040698.6, ENSRNOT00000040029.7

Conserved Domains (3) summary

cd11559
Location:1433 → 1562

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1234 → 1346

MA3; MA3 domain

pfam02854
Location:757 → 985

MIF4G; MIF4G domain
XM_063270355.1 → XP_063126425.1 eukaryotic translation initiation factor 4 gamma 1 isoform X15

UniProtKB/TrEMBL

D4AD15
XM_063270347.1 → XP_063126417.1 eukaryotic translation initiation factor 4 gamma 1 isoform X10

UniProtKB/TrEMBL

D4AD15
XM_063270344.1 → XP_063126414.1 eukaryotic translation initiation factor 4 gamma 1 isoform X8

UniProtKB/TrEMBL

D4AD15
XM_063270354.1 → XP_063126424.1 eukaryotic translation initiation factor 4 gamma 1 isoform X14

UniProtKB/TrEMBL

D4AD15
XM_063270351.1 → XP_063126421.1 eukaryotic translation initiation factor 4 gamma 1 isoform X13

UniProtKB/TrEMBL

D4AD15
XM_063270340.1 → XP_063126410.1 eukaryotic translation initiation factor 4 gamma 1 isoform X6

UniProtKB/TrEMBL

D4AD15
XM_006248585.5 → XP_006248647.1 eukaryotic translation initiation factor 4 gamma 1 isoform X5

See identical proteins and their annotated locations for XP_006248647.1

UniProtKB/TrEMBL

D4AD15

Conserved Domains (3) summary

cd11559
Location:1433 → 1562

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1234 → 1346

MA3; MA3 domain

pfam02854
Location:757 → 985

MIF4G; MIF4G domain
XM_006248581.5 → XP_006248643.1 eukaryotic translation initiation factor 4 gamma 1 isoform X1

See identical proteins and their annotated locations for XP_006248643.1

UniProtKB/TrEMBL

M0RD03

Conserved Domains (3) summary

cd11559
Location:1440 → 1569

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1241 → 1353

MA3; MA3 domain

pfam02854
Location:764 → 992

MIF4G; MIF4G domain
XM_017598182.3 → XP_017453671.1 eukaryotic translation initiation factor 4 gamma 1 isoform X1

UniProtKB/TrEMBL

M0RD03

Related

ENSRNOP00000049629.4, ENSRNOT00000041777.8

Conserved Domains (3) summary

cd11559
Location:1440 → 1569

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1241 → 1353

MA3; MA3 domain

pfam02854
Location:764 → 992

MIF4G; MIF4G domain
XM_063270341.1 → XP_063126411.1 eukaryotic translation initiation factor 4 gamma 1 isoform X6

UniProtKB/TrEMBL

D4AD15
XM_063270339.1 → XP_063126409.1 eukaryotic translation initiation factor 4 gamma 1 isoform X5

UniProtKB/TrEMBL

D4AD15
XM_063270349.1 → XP_063126419.1 eukaryotic translation initiation factor 4 gamma 1 isoform X11

UniProtKB/TrEMBL

D4AD15
XM_063270345.1 → XP_063126415.1 eukaryotic translation initiation factor 4 gamma 1 isoform X9

UniProtKB/TrEMBL

M0RD03
XM_063270342.1 → XP_063126412.1 eukaryotic translation initiation factor 4 gamma 1 isoform X7

UniProtKB/TrEMBL

M0RD03
XM_063270338.1 → XP_063126408.1 eukaryotic translation initiation factor 4 gamma 1 isoform X4

UniProtKB/TrEMBL

M0RD03
XM_063270336.1 → XP_063126406.1 eukaryotic translation initiation factor 4 gamma 1 isoform X2

UniProtKB/TrEMBL

D3ZU13, M0RD03
XM_063270337.1 → XP_063126407.1 eukaryotic translation initiation factor 4 gamma 1 isoform X3

UniProtKB/TrEMBL

M0RD03
XM_017598183.2 → XP_017453672.1 eukaryotic translation initiation factor 4 gamma 1 isoform X1

UniProtKB/TrEMBL

M0RD03

Conserved Domains (3) summary

cd11559
Location:1440 → 1569

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

pfam02847
Location:1241 → 1353

MA3; MA3 domain

pfam02854
Location:764 → 992

MIF4G; MIF4G domain
XM_063270358.1 → XP_063126428.1 eukaryotic translation initiation factor 4 gamma 1 isoform X18

UniProtKB/TrEMBL

D4AD15
XM_063270360.1 → XP_063126430.1 eukaryotic translation initiation factor 4 gamma 1 isoform X19

UniProtKB/TrEMBL

D4AD15
XM_063270356.1 → XP_063126426.1 eukaryotic translation initiation factor 4 gamma 1 isoform X16

UniProtKB/TrEMBL

D4AD15
XM_063270357.1 → XP_063126427.1 eukaryotic translation initiation factor 4 gamma 1 isoform X17

UniProtKB/TrEMBL

D4AD15