Cyfip1 cytoplasmic FMR1 interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyfip1provided by RGD
Official Full Name: cytoplasmic FMR1 interacting protein 1provided by RGD
Primary source: RGD:1310332
See related: EnsemblRapid:ENSRNOG00000011945 AllianceGenome:RGD:1310332
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables RNA 7-methylguanosine cap binding activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of synaptic vesicle recycling; and positive regulation of cell projection organization. Located in several cellular components, including dendritic spine; distal axon; and filopodium tip. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 305.6), Kidney (RPKM 283.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (115842754..115935163)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (106710924..106799393)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (114258773..114347138)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility.
Title: Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility.
Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.
Title: Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.
Dysregulation of CYFIP1 expression levels leads to pathological changes in CNS maturation and neuronal connectivity, both of which may contribute to the development of the neurological symptoms seen in ASD and SCZ.
Title: The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in axon extension	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in modification of synaptic structure	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation at postsynapse, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in central region of growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium tip	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peripheral region of growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytoplasmic FMR1-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107517.1 → NP_001100987.1 cytoplasmic FMR1-interacting protein 1

See identical proteins and their annotated locations for NP_001100987.1

Status: PROVISIONAL

Source sequence(s)

CH474036

UniProtKB/TrEMBL

A6KD28, D4A8H8

Related

ENSRNOP00000016376.5, ENSRNOT00000016376.7

Conserved Domains (1) summary

pfam05994
Location:389 → 1222

FragX_IP; Cytoplasmic Fragile-X interacting family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

115842754..115935163

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262343.1 → XP_063118413.1 cytoplasmic FMR1-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A6KD28, D4A8H8
XM_063262335.1 → XP_063118405.1 cytoplasmic FMR1-interacting protein 1 isoform X1

Related

ENSRNOP00000105554.1, ENSRNOT00000151113.1
XM_039112486.2 → XP_038968414.1 cytoplasmic FMR1-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A6KD28, D4A8H8

Conserved Domains (1) summary

pfam05994
Location:389 → 1222

FragX_IP; Cytoplasmic Fragile-X interacting family
XM_006229288.4 → XP_006229350.1 cytoplasmic FMR1-interacting protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K472

Related

ENSRNOP00000072931.1, ENSRNOT00000088459.3

Conserved Domains (1) summary

pfam05994
Location:389 → 1220

FragX_IP; Cytoplasmic Fragile-X interacting family
XM_039112492.1 → XP_038968420.1 cytoplasmic FMR1-interacting protein 1 isoform X4

Conserved Domains (1) summary

pfam05994
Location:389 → 970

FragX_IP; Cytoplasmic Fragile-X interacting family
XM_039112494.1 → XP_038968422.1 cytoplasmic FMR1-interacting protein 1 isoform X5

Conserved Domains (1) summary

cl23945
Location:389 → 695

FragX_IP; Cytoplasmic Fragile-X interacting family